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Graefe's Archive for Clinical and Experimental Ophthalmology

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18-12-2023 | Retinal Disorders

Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)

Authors: Ramesh Venkatesh, Rubble Mangla, Ashit Handa, Sai Prashanti Chitturi, Yash Parmar, Rohini Sangoram, Naresh Kumar Yadav, Jay Chhablani

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2024

Abstract

Purpose

To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development.

Methods

In this retrospective cross-sectional study, type 2 MacTel eyes with macular volumetric OCT imaging protocol were included to identify different types of VMIA such as abnormal PVD, vitreomacular traction (VMT), ERM, and lamellar and full-thickness macular hole. The VMIA findings were then correlated with different MacTel disease stages and visual acuity.

Results

One thousand forty-three OCTs of 332 type 2 MacTel eyes from 169 patients at different visits were examined. VMIA was detected in 709 (68%) of those OCT scans in 216 (65%) eyes. There were 273 (39%), 31 (4%), 89 (13%), 7 (1%), and 381 (54%) OCT scans with vitreomacular adhesion, VMT, ERM, and inner and outer lamellar macular holes discovered respectively. VMIA eyes had a high frequency of abnormal PVD (p = 0.001) and retinal pigment clumps (RPCs) [p = 0.032]. Eyes with abnormal PVD (p = 0.034) and RPC (p = 0.000) had a higher rate of ERM development. RPC was linked to an increased risk of developing ERM (odd ratio 2.472; 95% CI 1.488–4.052). RPC and ERM contributed significantly to poor visual acuity (0.661 ± 0.416, 20/92).

Conclusion

OCT reveals a high frequency of VMIA in advanced type 2 MacTel eyes. RPC could be responsible for the development of anomalous PVD, as well as subsequent VMIAs and ERM. Additional work is required to examine the long-term changes and surgical outcomes of these eyes.

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Title: Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)
Authors: Ramesh Venkatesh
Rubble Mangla
Ashit Handa
Sai Prashanti Chitturi
Yash Parmar
Rohini Sangoram
Naresh Kumar Yadav
Jay Chhablani
Publication date: 18-12-2023
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2024
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06330-8

EASD 2024

Springer Medicine

Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)

Abstract

Purpose

Methods

Results

Conclusion

EASD 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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