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Open Access 18-09-2023 | Vitamin D Deficiency | Review

Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review

Authors: Chiara Ceolin, M. V. Papa, M. De Rui, M. Devita, G. Sergi, A. Coin

Published in: The journal of nutrition, health & aging | Issue 9/2023

Abstract

Background and Objectives

One of the pathogenetic hypotheses of delirium is the “neuroinflammatory theory” with consequent neurotoxicity of brain connectivity networks. Micronutrients may play a significant role in the prevention of neuroinflammation. This systematic review addresses the role of micronutrients in the development of delirium in older populations.

Methods

The EBSCO, Cochrane, PubMed, and Web of Science databases were searched for articles on delirium and micronutrients. The methodological quality of the studies included in the review was evaluated with the Newcastle-Ottawa Scales for observational studies and for case-control studies.

Results

1326 papers were identified from the searches, 7 of which met the inclusion criteria (see section 2.3). All the papers included were written in English. Delirium was predominantly secondary to post-operative dysfunction or acute medical conditions. By altering the production of neurotransmitters resulting in an imbalance, and by reducing their immunomodulatory role with a consequent increase in inflammatory oxidative stress, micronutrient deficiency seems to be associated with an increased incidence of delirium.

Conclusions

This review supports the existence of an association between micronutrient deficiency (i.e. cobalamin, thiamine, and vitamin D) and an increased incidence of delirium, with a greater prevalence in hospitalized patients.

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Title: Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review
Authors: Chiara Ceolin
M. V. Papa
M. De Rui
M. Devita
G. Sergi
A. Coin
Publication date: 18-09-2023
Publisher: Springer Paris
Keyword: Vitamin D Deficiency
Published in: The journal of nutrition, health & aging / Issue 9/2023
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-023-1976-z

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Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review

Abstract

Background and Objectives

Methods

Results

Conclusions

Test your knowledge with Case-Based Clinical Insights

Oncology and Hematology Cases

28/♂ with dorsal pain and bulging of the abdominal wall – Case 1

46/♂ with tendency to infection – Case 2

76/♀ with subacute gait disorder and yellowish pallor – Case 3

56/♂ with dorsal pain and concentration problems – Case 4

Navigating the Treatment of Renal Cell Carcinoma

Insights on the Current Treatment Landscape and Managing Patient Health

ERS International Congress 2023

Springer Medicine

Abstract

Background and Objectives

Methods

Results

Conclusions

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