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Familial Cancer

Surgery in NF2-Schwannomatosis

Published in:
Authors
Michel Kalamarides
Omar Pathmanaban
Matthieu Peyre
Andrew Thomas King
Published in
Familial Cancer | Issue 1/2026

Abstract

NF2-Schwannomatosis (NF2-SWN) is a disease characterized by multiple tumors of the central and peripheral nervous system. Surgery remains an important treatment option, sometimes performed on an urgent basis, but usually planned within the context of complex multi-tumour burden and morbidity. It is difficult to provide a comprehensive generic decision tree because each patient has a unique disease burden, but we will detail in this review the therapeutic indications for each tumor type, vestibular schwannomas, meningiomas, spinal schwannomas and meningiomas, spinal ependymomas and peripheral schwannomas. The experience of the multidisciplinary team impact outcomes in this rare disease and centralized care has been shown to improve the disease course.
Title
Surgery in NF2-Schwannomatosis
Authors
Michel Kalamarides
Omar Pathmanaban
Matthieu Peyre
Andrew Thomas King
Publication date
01-03-2026
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 1/2026
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-025-00522-3
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Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images