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Pulmonary arteritis in GPA

Pulmonary arteritis is a very rare manifestation of granulomatosis with polyangiitis, which typically involves small- and medium-sized vessels. But this case highlights the possibility of large-vessel inflammation.

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Editor's Choice

Safety of rapid rituximab infusion in rheumatic diseases

A systematic evaluation of the evidence for accelerated infusion of rituximab in people autoimmune rheumatic diseases. The practice appears safe and feasible but prospective studies are needed.

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

Kidney involvement in VEXAS syndrome

VEXAS syndrome is a recently identified genetic autoinflammatory disorder. This case highlights its under-recognized renal manifestations and underscores the need for heightened clinical suspicion and earlier intervention.

Precision over prednisone: innovation in GCA treatment

Tocilizumab has emerged as a promising treatment option for giant cell arteritis, demonstrating significant potential to reduce glucocorticoid dependence. But unanswered questions remain, such as the optimal duration of therapy.

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Case Studies

Pulmonary arteritis in GPA

Pulmonary arteritis is a very rare manifestation of granulomatosis with polyangiitis, which typically involves small- and medium-sized vessels. But this case highlights the possibility of large-vessel inflammation.

Kidney involvement in VEXAS syndrome

VEXAS syndrome is a recently identified genetic autoinflammatory disorder. This case highlights its under-recognized renal manifestations and underscores the need for heightened clinical suspicion and earlier intervention.

Takayasu arteritis complicated by SAPHO syndrome

Two patients presenting with anterior chest pain were diagnosed with Takayasu arteritis co-existing with SAPHO syndrome, a rare inflammatory osteoarticular disorder. Their symptoms improved with glucocorticoids and biologic agents.

Current Reviews

A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma

Takayasu arteritis (TAK) is a large vessel vasculitis characterized by granulomatous inflammation of aorta and its major branches [ 1 ]. It mainly occurs in young female patients and is much less common among children than adults [ 2 ]. The annual …

Public Health Impact of Kawasaki Disease in India: Projections for 2030

Kawasaki disease (KD) is a systemic vasculitis that usually affects children below 5 years and has now become the leading cause of acquired heart disease in children, surpassing acute rheumatic fever. Incidence data from Chandigarh, India, between …

Treatment and long-term follow-up of pediatric patients with hypocomplementemic urticarial vasculitis syndrome (HUVS): a case-based review

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare, severe form of urticarial vasculitis. It is characterized by persistent hypocomplementemia, chronic urticarial vasculitic lesions, and severe multiorgan involvement. Herein, we …

Aging in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: From Pathophysiology to Clinical Management

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) predominantly affect individuals aged 55–75 years, with granulomatosis with polyangiitis (GPA) being diagnosed most often between 55 and 65 years and microscopic polyangiitis …

Further Reading

A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma

Takayasu arteritis (TAK) is a large vessel vasculitis characterized by granulomatous inflammation of aorta and its major branches [ 1 ]. It mainly occurs in young female patients and is much less common among children than adults [ 2 ]. The annual …

Intraocular inflammation following intravitreal injections of anti-vascular endothelial growth factor drugs

The Intravitreal injections (IVI) of anti-vascular endothelial growth factor (VEGF) agents are commonly used as the treatment of choice for patients with macular neovascularization or macular edema from different etiologies, aiming to improve both …

The Impact of COVID-19 on Graft Vasculopathy and Postoperative Thromboembolism in CABG Patients: A Prospective Controlled Study

It is known that COVID-19 patients may experience endothelial cell inflammation, apoptosis, dysfunction, and systemic coagulation disorders. In CABG operations, graft patency plays a crucial role in survival and morbidity. Thrombosis and …

Treatment and long-term follow-up of pediatric patients with hypocomplementemic urticarial vasculitis syndrome (HUVS): a case-based review

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare, severe form of urticarial vasculitis. It is characterized by persistent hypocomplementemia, chronic urticarial vasculitic lesions, and severe multiorgan involvement. Herein, we …