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Open Access 29-01-2025 | Vaccination | Research

Longterm efficacy of a patient focused intervention in patients with asplenia– a three year follow-up of the PrePPS trial

Authors: Johannes Camp, Valerie Heine, Marianne Bayrhuber, Natascha Anka, Manuela Glattacker, Erik Farin-Glattacker, Siegbert Rieg

Published in: Infection

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Abstract

Objectives

This study aimed to reassess the long-term impact of a Health Action Process Approach (HAPA)-informed intervention on guideline adherence among asplenic patients and their physicians, three years post-intervention.

Methods

This follow-up study was conducted within the framework of the interventional PrePSS (Prevention of Postsplenectomy Sepsis Score) study. Patients aged 18 or older with anatomical asplenia were in enrolled in a prospective controlled, two-armed historical control group design. The intervention group received tailored educational materials, medical alert cards, and a telephonic HAPA-based intervention. A telephonic follow-up assessment was conducted three years post-intervention, evaluating adherence to preventive measures using the PrePSS-score (range 0–10) and propensity-score based overlap weighting.

Results

Out of 106 patients who had received the intervention, 79 (75%) completed the three-year follow-up. The PrePSS-scores further increased compared to six months post-intervention (median of 8.08 points vs 7.60 points), with notable improvements in vaccination coverage and availability of emergency antibiotics. Only four participants reported severe infections requiring hospitalization, none of which were typical of post-splenectomy sepsis. 47/79 (59%) of participants contracted SARS-CoV2 but clinical courses were mild with only one patient needing hospital and ICU treatment.

Conclusions

Patients who had received our novel telephonic intervention exhibited significant and sustained improvement in adherence to guideline-based preventive measures at three years post intervention. HAPA-based interventions may yield more sustained effects than traditional nudging strategies.
Literature
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go back to reference Tonapa I, Santo; Inayati, Aini; Sithichoksakulchai, Siriluk; DaryantiSaragih, Ita; Efendi, Ferry; Chou, Fan-Hao,. Outcomes of nurse-led telecoaching intervention for patients with heart failure: A systematic review and meta-analysis of randomised controlled trials. J Clin Nursing. 2022. https://doi.org/10.1111/jocn.16025.CrossRef Tonapa I, Santo; Inayati, Aini; Sithichoksakulchai, Siriluk; DaryantiSaragih, Ita; Efendi, Ferry; Chou, Fan-Hao,. Outcomes of nurse-led telecoaching intervention for patients with heart failure: A systematic review and meta-analysis of randomised controlled trials. J Clin Nursing. 2022. https://​doi.​org/​10.​1111/​jocn.​16025.CrossRef
Metadata
Title
Longterm efficacy of a patient focused intervention in patients with asplenia– a three year follow-up of the PrePPS trial
Authors
Johannes Camp
Valerie Heine
Marianne Bayrhuber
Natascha Anka
Manuela Glattacker
Erik Farin-Glattacker
Siegbert Rieg
Publication date
29-01-2025
Publisher
Springer Berlin Heidelberg
Published in
Infection
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-025-02472-5

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