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Endocrine
Published in:

09-07-2022 | Vaccination | Original Article

Type 1 diabetes mellitus following SARS-CoV-2 mRNA vaccination

Authors: Berna İmge Aydoğan, Uğur Ünlütürk, Mustafa Cesur

Published in: Endocrine | Issue 1/2022

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Abstract

Purpose

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines have been reported to trigger immune side effects. Type 1 diabetes as a manifestation of autoimmune/inflammatory syndrome induced by adjuvants has been reported in a limited number of cases after vaccinations. A few type 1 diabetes cases after SARS-CoV-2 vaccination have been reported. This study aims to report type 1 diabetes cases associated with the mRNA-based SARS-CoV-2 vaccination.

Methods

We report four cases of type 1 diabetes mellitus after mRNA-based SARS-CoV-2 vaccine, BNT162b2 (Pfizer–BioNTech). In the medical history, one subject had autoimmune thyroid disease. All patients had autoantibodies against glutamate decarboxylase.

Results

In the presented case series, type 1 diabetes developed a few weeks after BNT162b2 vaccination. After developing type 1 diabetes, the insulin dose requirements of all patients decreased rapidly, and the need for insulin therapy in three patients disappeared during follow-up. Acute deterioration of glucose regulation in a patient followed by BNT162b2 administration may be due to vaccine-induced autoimmune diabetes.

Conclusion

Vaccination with BNT162b2 may trigger type 1 diabetes.
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Metadata
Title
Type 1 diabetes mellitus following SARS-CoV-2 mRNA vaccination
Authors
Berna İmge Aydoğan
Uğur Ünlütürk
Mustafa Cesur
Publication date
09-07-2022
Publisher
Springer US
Published in
Endocrine / Issue 1/2022
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-022-03130-8

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