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Open Access 01-12-2024 | Urinary Tract Infection | Research

Multidrug resistance in urinary E. coli higher in males compared to females

Authors: Narayan Khanal, Colin H. Cortie, Chloe Story, Sandra Jones, Kylie J. Mansfield, Spiros Miyakis, Caitlin Keighley

Published in: BMC Urology | Issue 1/2024

Abstract

Background

Urinary tract infections (UTIs) are common however the widespread use of antibiotics has led to a rise in antimicrobial resistance (AMR) amongst uropathogens, rendering a significant proportion of infections resistant to first line treatment. AMR in UTIs may differentially affect men and women, younger and older patients. The purpose of this study was to investigate MDR (multi-drug resistance) and AMR in males and females in an Australian health district.

Methods

There were 85,844 E. coli urinary isolates (2007–2020) analysed from adult patients. An E. coli isolate with MDR was defined as resistant to at least 1 agent in ≥ 3 antimicrobial classes. Chi-square tests and relative risk were calculated by comparing resistance in males and females and by age for antibiotics commonly used to treat UTIs in hospital and community collected samples.

Results

There was a higher proportion of MDR E. coli in males compared to females in both the community (6.4% vs. 5.2%, P < 0.001) and hospital datasets (16.5% vs. 12.8%, P < 0.001). The proportions of MDR for both males and females were significantly higher in the hospital setting. Resistance rates were higher in males compared to females for amoxicillin, amoxicillin/clavulanate, cephalexin and norfloxacin (p < 0.005), though not for trimethoprim. Antibiotic resistance was seen to increase over time.

Conclusions

A higher proportion of MDR E. coli were noted in urine samples from males compared with females, possibly due to the increased likelihood of prior treatment for UTIs in men. Antimicrobial stewardship interventions could be targeted towards this cohort to address increasing rates of AMR.

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Title: Multidrug resistance in urinary E. coli higher in males compared to females
Authors: Narayan Khanal
Colin H. Cortie
Chloe Story
Sandra Jones
Kylie J. Mansfield
Spiros Miyakis
Caitlin Keighley
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Urinary Tract Infection
Antibiotic
Amoxicillin
Published in: BMC Urology / Issue 1/2024
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-024-01654-x

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Multidrug resistance in urinary E. coli higher in males compared to females

Abstract

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