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Published in: The International Journal of Cardiovascular Imaging 3/2023

Open Access 21-01-2023 | Ultrasound | OriginalPaper

Carotid wall echogenicity at baseline associates with accelerated vascular aging in a middle-aged population

Authors: Emma Nyman, Per Liv, Per Wester, Ulf Näslund, Christer Grönlund

Published in: The International Journal of Cardiovascular Imaging | Issue 3/2023

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Abstract

Ultrasonic echolucent carotid intima-media (IM) complex and accelerated progression of carotid intima mediathickness (cIMT) have both separately been shown to predict future cardiovascular events. The aim of this studywas to evaluate if the echogenicity of the IM-complex is associated with the 3-year progression of cIMT. B-modeultrasound images captured at baseline and 3-year follow-up in the ‘Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention’ (VIPVIZA) trial were included (n: 3154). The bilateral mean cIMT and IM-echogenicity by greyscale median (GSM) were measured in the common carotid artery. Associations between IM-GSM at baseline and the 3-year cIMT progression were investigated using linear regression models for the whole population and stratified by sex, age and VIPVIZA study group (intervention versus control). In addition, adjusted analyses for confounding factors were performed. Unadjusted analysis showed that decreased IM-GSM at baseline was associated with increased progression of cIMT (p < 0.001). Stratified by age, the association was significant among 40 (p < 0.001) and 60 years old (p < 0.001). The association was statistically significant in both sexes and on comparison of VIPVIZA study subgroups. Adjustments for confounding factors did not alter the estimated relationship between IM-GSM and cIMT progression. Echolucent carotid intima media at baseline associates with increased 3-year cIMT progression among an asymptomatic, middle-aged population. Echogenicity of the intima media may identify individuals at risk for accelerated vascular aging.
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Metadata
Title
Carotid wall echogenicity at baseline associates with accelerated vascular aging in a middle-aged population
Authors
Emma Nyman
Per Liv
Per Wester
Ulf Näslund
Christer Grönlund
Publication date
21-01-2023
Publisher
Springer Netherlands
Published in
The International Journal of Cardiovascular Imaging / Issue 3/2023
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-022-02760-3

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