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Published in: Inflammopharmacology 1/2024

19-10-2023 | Ulcerative Colitis | Original Article

Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model

Authors: Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh

Published in: Inflammopharmacology | Issue 1/2024

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Abstract

Ulcerative colitis is a chronic inflammatory disorder of the intestinal mucosa and a prevalent gastrointestinal condition in developed countries. Peiminine, derived from the Fritillaria imperialis plant, exhibits remarkable anti-inflammatory and anti-cancer properties. This study aims to investigate the anti-inflammatory effects of peiminine in an experimental model of ulcerative colitis. Ulcerative colitis was induced intra-rectally in all groups, except the negative control, using 100 μl of 4% acetic acid. Peiminine treatment was initiated after ulcerative colitis induction and symptom manifestation. After the final injection, mice were sacrificed on day 15 for assessment. Various parameters were evaluated, including disease activity index, myeloperoxidase activity, nitric oxide levels, production and expression of IL-1, IL-6, TNF-α cytokines, and expression of IL-1β, IL-6, TNF-α, iNOS, and COX2 genes. Microscopic pathological evaluation was performed on colon tissue. Peiminine treatment resulted in reduced levels of NO, MPO, IL-1β, IL-6, and TNF-α. Furthermore, the expression of IL-1β, IL-6, TNF-α genes, iNOS, and COX2 genes was decreased in response to peiminine treatment in these mice. This study demonstrates the effectiveness of peiminine in alleviating inflammatory manifestations and mitigating intestinal tissue damage in an experimental model of ulcerative colitis, probably by anti-inflammatory procedure. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
Literature
go back to reference Tehranipour M, Emamyian Zaman M, Vaezi GH, Nejad Shahrokh Abadi K (2018) The effect of aqueous extract of Cichorium intybus L. stem on the biochemical parameters of serum and urine in male rats with nephrolithiasis. Iran J Biol Sci 13:53–61 Tehranipour M, Emamyian Zaman M, Vaezi GH, Nejad Shahrokh Abadi K (2018) The effect of aqueous extract of Cichorium intybus L. stem on the biochemical parameters of serum and urine in male rats with nephrolithiasis. Iran J Biol Sci 13:53–61
Metadata
Title
Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model
Authors
Maryam Ranjbar Bushehri
Nahid Babaei
Hadi Esmaeili Gouvarchin Ghaleh
Gholamreza Khamisipour
Gholamreza Farnoosh
Publication date
19-10-2023
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 1/2024
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01360-4

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