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Published in: Journal of Natural Medicines 3/2024

25-04-2024 | Note

Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam

Authors: Yuan-Yuan Zhou, Zhao Sun, Yan Liu, Zhen-Xing Fang, Hui-Rui Gao, Ning-Yu Liu, Xiao-Juan Zhang, Bing-You Yang, Hai-Xue Kuang

Published in: Journal of Natural Medicines | Issue 3/2024

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Abstract

Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3–12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC50 values in the range of 25.15–88.85 μM except for 912.

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Metadata
Title
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Authors
Yuan-Yuan Zhou
Zhao Sun
Yan Liu
Zhen-Xing Fang
Hui-Rui Gao
Ning-Yu Liu
Xiao-Juan Zhang
Bing-You Yang
Hai-Xue Kuang
Publication date
25-04-2024
Publisher
Springer Nature Singapore
Published in
Journal of Natural Medicines / Issue 3/2024
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01793-3

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