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Indian Journal of Pediatrics

20-11-2023 | Tuberculosis | Review Article

Post-tuberculosis Sequelae in Children

Authors: Ritika Goyal, Ankit Parakh

Published in: Indian Journal of Pediatrics

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Abstract

Tuberculosis (TB) is a global health problem especially in the Indian subcontinent imposing significant physical, psychosocial and economic burden on the society. Most national programs define TB cure as completion of treatment with improvement in clinical symptoms, microbiological and radiological clearance. However, follow up these patients for long-term sequelae or complications has not got adequate attention. Post-TB lung disease, neurological deficits and spinal deformities are some of the post-TB sequelae reported in adults, with scanty data available for children. With this review authors attempt to discuss various post-TB disease manifestations and the risk factors associated with their development in children. They address the need to create awareness amongst physicians involved in managing children with TB and obtain more scientific data in this field.
Literature
1.
2.
3.
Menzies NA, Quaife M, Allwood BW, et al. Lifetime burden of disease due to incident tuberculosis: A global reappraisal including post-tuberculosis sequelae [correction in Lancet Glob Health. 2022;10:e336]. Lancet Glob Health. 2021;9:e1679–87. CrossRefPubMedPubMedCentral
4.
Igbokwe V, Ruby LC, Sultanli A, Bélard S. Post-tuberculosis sequelae in children and adolescents: A systematic review. Lancet Infect Dis. 2023;23:e138–50. CrossRefPubMed
5.
Nkereuwem E, Agbla S, Sallahdeen A, et al. Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: A cross-sectional comparative study. Thorax. 2023;78:281–7. CrossRefPubMed
6.
Martinez L, Gray DM, Botha M, et al. The long-term impact of early-life tuberculosis disease on child health: A prospective birth cohort study. Am J Respir Crit Care Med. 2023;207:1080–8. CrossRefPubMedPubMedCentral
7.
Soriano-Arandes A, Brugueras S, Rodríguez Chitiva A, et al. Clinical presentations and outcomes related to tuberculosis in children younger than 2 years of age in Catalonia. Front Pediatr. 2019;7:238. CrossRefPubMedPubMedCentral
8.
Choi H, Lee H, Ra SW, et al. Clinical characteristics of patients with post-tuberculosis bronchiectasis: Findings from the KMBARC registry. J Clin Med. 2021;10:4542. CrossRefPubMedPubMedCentral
9.
Allwood BW, Byrne A, Meghji J, Rachow A, van der Zalm MM, Schoch OD. Post-tuberculosis lung disease: Clinical review of an under-recognised global challenge. Respiration. 2021;100:751–63. CrossRefPubMed
10.
Yang M-J, He J-Q, Guo S-L. Tracheobronchial tuberculosis and its sequelae in children and adolescents. Lancet Infec Dis. 2023;23:786. CrossRef
11.
Maleche-Obimbo E, Odhiambo MA, Njeri L, et al. Magnitude and factors associated with post-tuberculosis lung disease in low- and middle-income countries: A systematic review and meta-analysis. PLOS Glob Public Health. 2022;2:e0000805. CrossRefPubMedPubMedCentral
12.
Creswell J, Raviglione M, Ottmani S, et al. Tuberculosis and noncommunicable diseases: Neglected links and missed opportunities. Eur Respir J. 2011;37:1269–82. CrossRefPubMed
13.
Rachow A, Ivanova O, Wallis R, et al. TB sequel: Incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB – a study protocol. BMC Pulm Med. 2019;19:4. CrossRefPubMedPubMedCentral
14.
Ralph AP, Kenangalem E, Waramori G, et al. High morbidity during treatment and residual pulmonary disability in pulmonary tuberculosis: Under-recognised phenomena. PLoS ONE. 2013;8:e80302. CrossRefPubMedPubMedCentral
15.
de Vallière S, Barker RD. Residual lung damage after completion of treatment for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2004;8:767–71. PubMed
16.
Githinji LN, Gray DM, Hlengwa S, Myer L, Zar HJ. Lung function in South African adolescents infected perinatally with HIV and treated long-term with antiretroviral therapy. Ann Am Thorac Soc. 2017;14:722–9. CrossRefPubMedPubMedCentral
17.
Schoeman J, Wait J, Burger M, et al. Long-term follow up of childhood tuberculous meningitis. Dev Med Child Neurol. 2002;44:522–6. CrossRefPubMed
18.
Wait JW, Schoeman JF. Behaviour profiles after tuberculous meningitis. J Trop Pediatr. 2010;56:166–71. CrossRefPubMed
19.
Mohan J, Rakesh PS, Moses PD, Varkki S. Outcome of children with tuberculous meningitis: A prospective study from a tertiary care centre in Southern India. Int J Community Med Public Health. 2016;4:220–3. CrossRef
20.
Faella FS, Pagliano P, Attanasio V, et al. Factors influencing the presentation and outcome of tuberculous meningitis in childhood. In Vivo. 2006;20:187–91. PubMed
21.
Lam KS, Sham MM, Tam SC, Ng MM, Ma HT. Hypopituitarism after tuberculous meningitis in childhood. Ann Intern Med. 1993;118:701–6. CrossRefPubMed
22.
Duque-Silva A, Hampole V, Cheng YN, Flood J, Barry PM. Outcomes of pediatric central nervous system tuberculosis in California, 1993–2011. J Pediatric Infect Dis Soc. 2019;8:439–49. CrossRefPubMed
23.
Chiang SS, Khan FA, Milstein MB, et al. Treatment outcomes of childhood tuberculous meningitis: A systematic review and meta-analysis. Lancet Infect Dis. 2014;14:947–57. CrossRefPubMed
24.
Prasad K, Singh MB, Ryan H. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2016;4:CD002244. PubMed
25.
Rajasekaran S. Buckling collapse of the spine in childhood spinal tuberculosis. Clin Orthop Relat Res. 2007;460:86–92. CrossRefPubMed
26.
27.
Yau AC, Hsu LC, O’Brien JP, Hodgson AR. Tuberculous kyphosis: Correction with spinal osteotomy, halo-pelvic distraction and anterior and posterior fusion. J Bone Joint Surg Am. 1974;56:1419–34. CrossRefPubMed
28.
Rajasekaran S, Prasad Shetty A, Dheenadhayalan J, Shashidhar Reddy J, Naresh-Babu J, Kishen T. Morphological changes during growth in healed childhood spinal tuberculosis: A 15-year prospective study of 61 children treated with ambulatory chemotherapy. J Pediatr Orthop. 2006;26:716–24. CrossRefPubMed
29.
Rajasekaran S. The natural history of post-tubercular kyphosis in children. Radiological signs which predict late increase in deformity. J Bone Joint Surg Br. 2001;83:954–62. CrossRefPubMed
30.
31.
Shekar PA, Patel H, Dumra A, Reddy D, Shivakumar KS, Kumar PS. Presentation, management and outcomes of pediatric urogenital tuberculosis: 20 years’ experience from a tertiary center. J Pediatr Urol. 2021;17:546.E1–8. CrossRef
32.
Allwood BW, van der Zalm MM, Amaral AFS, et al. Post-tuberculosis lung health: Perspectives from the first international symposium. Int J Tuberc Lung Dis. 2020;24:820–8. CrossRefPubMed
Metadata
Title
Post-tuberculosis Sequelae in Children
Authors
Ritika Goyal
Ankit Parakh
Publication date
20-11-2023
Publisher
Springer India
Published in
Indian Journal of Pediatrics
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-023-04912-2