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tRNA m2G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation

  • Open Access
  • 13-01-2026
  • Research
Title
tRNA m2G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation
Authors
Wenbin Yuan
Shi Li
Yue Xi
Rui Tian
Yuan Liu
Xingyu Chen
Rui Zhang
Hao Lyu
Shuai Xiao
Dong Guo
Qi Zhang
Wenying Qin
Chaojun Yan
Xing-Zhen Chen
Cefan Zhou
Jingfeng Tang
Publication date
13-01-2026
Publisher
BioMed Central
Published in
Molecular Cancer
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-025-02540-2

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Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images