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Journal of Neuro-Oncology

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20-11-2023 | Research

Treatment and survival of patients with small cell lung cancer and brain metastasis

Authors: Chi-Lu Chiang, Huai-Che Yang, Ying-Ting Liao, Yung-Hung Luo, Yuan-Hung Wu, Hsiu-Mei Wu, Yuh-Min Chen

Published in: Journal of Neuro-Oncology | Issue 2/2023

Abstract

Purpose

To elucidate treatment patterns and their outcomes in patients with small cell lung cancer (SCLC) and brain metastasis (BM).

Methods

In this retrospective study, patients with SCLC and BM were stratified by treatment modality into three groups: those treated with systemic therapy only, those treated with stereotactic radiosurgery (SRS) and systemic therapy, and those treated with whole-brain radiotherapy (WBRT) and systemic therapy. The primary outcomes were overall survival (OS) and time to central nervous system progression (TTCP).

Results

The analysis included 149 patients. After BM diagnosis, 48 patients (32.2%) received systemic therapy alone, 33 received SRS with systemic therapy, and 68 received WBRT with systemic therapy. The median OS and TTCP were 7.2 months and 8.7 months, respectively. Patients receiving WBRT with systemic therapy exhibited better intracranial control, but not better OS, than did the other patients. Key prognostic factors affecting OS were age, BM lesion count, chemotherapy, and immunotherapy. Notably, the Eastern Cooperative Oncology Group performance status and BM lesion count significantly influenced intracranial control in patients treated with SRS and systemic therapy.

Conclusion

Although WBRT combined with systemic therapy offer better intracranial control in patients with SCLC and BM, this approach is not superior to the other approaches in terms of OS benefits. Emerging systemic therapies, such as immunotherapy, may be used as alternative or adjunctive treatments for specific patient populations. Further studies are warranted to refine treatment selection.

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Title: Treatment and survival of patients with small cell lung cancer and brain metastasis
Authors: Chi-Lu Chiang
Huai-Che Yang
Ying-Ting Liao
Yung-Hung Luo
Yuan-Hung Wu
Hsiu-Mei Wu
Yuh-Min Chen
Publication date: 20-11-2023
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2023
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-023-04512-2

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Treatment and survival of patients with small cell lung cancer and brain metastasis

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

Purpose

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