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Current Cardiology Reports

Transcatheter Structural Heart Interventions in Women

Published in:
Authors
Jina Chung
Katharine Yang
Nino Nozadze
Aparna Kukarni
Mahi Ashwath
Quang Bui
Jennifer Co-Vu
Pei-Ni Jone
Radmila Lyubarova
Sharon Andrade-Bucknor
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

To provide a review of current transcatheter structural heart interventions in women, with a focus on sex-specific considerations in diagnosis, treatment and outcomes.

Recent Findings

Transcatheter interventions have transformed structural heart disease treatment, including valvular heart disease and left atrial appendage closure. Historically, low female enrollment in cardiovascular trials has limited sex-specific data integration into clinical guidelines. Recently, the changing landscape of female representation has provided insight into distinct pathophysiology, high-risk features, clinical characteristics, disease surveillance, referral barriers, and treatment responses.

Summary

The success of transcatheter structural heart interventions relies on judicious patient selection and timely intervention. This review evaluates contemporary female representation in transcatheter studies, highlighting sex-specific prevalence, anatomic and physiologic variations, clinical presentations and both short- and long-term outcomes. Knowledge gaps and future research directions are identified to address diagnostic and therapeutic disparities, ultimately improving individualized lifetime care in women with structural heart disease.
Title
Transcatheter Structural Heart Interventions in Women
Authors
Jina Chung
Katharine Yang
Nino Nozadze
Aparna Kukarni
Mahi Ashwath
Quang Bui
Jennifer Co-Vu
Pei-Ni Jone
Radmila Lyubarova
Sharon Andrade-Bucknor
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02254-3
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME