Skip to main content
Top
Published in:

09-05-2024 | Original Research Paper

Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway

Authors: Liang Liu, Lingjuan Zhu, Qian Liang, Lingling Yu, Longlong Hu, Yun Yu, Xiaoshu Cheng, Huihui Bao

Published in: Inflammation Research | Issue 7/2024

Login to get access

Abstract

Objective

Resident immune cells are at the forefront of sensory organ-specific signals, and changes in these cells are closely related to the aging process. The Sirt pathway can regulate NAD + metabolism during aging, thereby affecting the accumulation of ROS. However, the role of the Sirt pathway in resident immune cells in aged tissues is currently unclear.

Methods

We investigated Sirt1 signalling in resident immune cells during chronic inflammation in an aged mouse model. Integrated single-cell RNA sequencing data from young and aged mice were used to refine the characterization of immune cells in aged tissues

Results

We found that C1q + macrophages could affect chronic inflammation during aging. C1q + macrophages acted in an opposing manner to Il1b + macrophages and were responsible for anti-inflammatory effects during aging. Sirt1 agonists inhibited the decrease in C1qb in macrophages during aging, and anti-aging drugs could affect the expression of C1qb in macrophages via the Sirt1 pathway.

Conclusions

In this study, we first identified the relevance of C1q + macrophages in chronic inflammation during aging. The potential anti-aging effect of C1q + macrophages was mediated by the Sirt1 pathway, suggesting new strategies for aging immunotherapy.
Appendix
Available only for authorised users
Literature
6.
go back to reference Mannick JB, et al. TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci Transl Med. 2018;10(449):eaaq1564.CrossRefPubMed Mannick JB, et al. TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci Transl Med. 2018;10(449):eaaq1564.CrossRefPubMed
7.
go back to reference Lefèvre L, et al. Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors. Cell Mol Life Sci. 2021;78(7):3485–501.CrossRefPubMed Lefèvre L, et al. Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors. Cell Mol Life Sci. 2021;78(7):3485–501.CrossRefPubMed
8.
go back to reference Prieto LI, et al. Senescent alveolar macrophages promote early-stage lung tumorigenesis. Cancer Cell. 2023;41(7):1261–75.CrossRefPubMed Prieto LI, et al. Senescent alveolar macrophages promote early-stage lung tumorigenesis. Cancer Cell. 2023;41(7):1261–75.CrossRefPubMed
10.
11.
go back to reference Chang HC, Guarente L. SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab. 2014;25(3):138–45.CrossRefPubMed Chang HC, Guarente L. SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab. 2014;25(3):138–45.CrossRefPubMed
13.
14.
15.
go back to reference Mogilenko DA, et al. Comprehensive profiling of an aging immune system reveals clonal GZMK(+) CD8(+) t cells as conserved Hallmark of inflammaging. Immunity. 2021;54(1):99-115.e12.CrossRefPubMed Mogilenko DA, et al. Comprehensive profiling of an aging immune system reveals clonal GZMK(+) CD8(+) t cells as conserved Hallmark of inflammaging. Immunity. 2021;54(1):99-115.e12.CrossRefPubMed
16.
go back to reference Xie W, et al. Single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing reveals cellular and molecular dynamics of aortic aging in mice. Arterioscler Thromb Vasc Biol. 2022;42(2):156–71.CrossRefPubMed Xie W, et al. Single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing reveals cellular and molecular dynamics of aortic aging in mice. Arterioscler Thromb Vasc Biol. 2022;42(2):156–71.CrossRefPubMed
17.
go back to reference Hu C, et al. Cell marker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 2023;51(D1):D870–6.CrossRefPubMed Hu C, et al. Cell marker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 2023;51(D1):D870–6.CrossRefPubMed
19.
go back to reference Franceschi C, et al. Inflammaging and ‘Garb-aging.’ Trends Endocrinol Metab. 2017;28(3):199–212.CrossRefPubMed Franceschi C, et al. Inflammaging and ‘Garb-aging.’ Trends Endocrinol Metab. 2017;28(3):199–212.CrossRefPubMed
20.
go back to reference Furman D, et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017;23(2):174–84.CrossRefPubMedPubMedCentral Furman D, et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017;23(2):174–84.CrossRefPubMedPubMedCentral
22.
go back to reference Mitchell DA, et al. C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 2002;168(5):2538–43.CrossRefPubMed Mitchell DA, et al. C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 2002;168(5):2538–43.CrossRefPubMed
23.
go back to reference Pulanco MC, et al. Complement protein C1q enhances macrophage foam cell survival and efferocytosis. J Immunol. 2017;198(1):472–80.CrossRefPubMed Pulanco MC, et al. Complement protein C1q enhances macrophage foam cell survival and efferocytosis. J Immunol. 2017;198(1):472–80.CrossRefPubMed
24.
27.
go back to reference Luo Y, et al. Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy. Aging (Albany NY). 2020;12(2):1704–24.CrossRefPubMed Luo Y, et al. Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy. Aging (Albany NY). 2020;12(2):1704–24.CrossRefPubMed
28.
go back to reference Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119–41.CrossRefPubMed Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119–41.CrossRefPubMed
29.
go back to reference Minhas PS, et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63.CrossRefPubMed Minhas PS, et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63.CrossRefPubMed
Metadata
Title
Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway
Authors
Liang Liu
Lingjuan Zhu
Qian Liang
Lingling Yu
Longlong Hu
Yun Yu
Xiaoshu Cheng
Huihui Bao
Publication date
09-05-2024
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 7/2024
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-024-01883-8

Other articles of this Issue 7/2024

Inflammation Research 7/2024 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Webinar | 06-02-2024 | 20:00 (CET)

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by: Viatris

Developed by: Springer Healthcare
Live Webinar | 01-10-2024 | 12:30 (CEST)

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

Live: Tuesday 1st October 2024, 12:30-14:00 (CEST)

In this live webinar, Professor Martin Dreyling and an esteemed, international panel of CAR-T experts will discuss the very latest data on the safety, efficacy and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL, as presented at ASH 2023, EU CAR-T 2024, and EHA 2024. 

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by: Novartis Pharma AG

Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare