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Open Access 22-09-2023 | Tinnitus

Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study

Authors: Sven Strebel, Katja Baust, Desiree Grabow, Julianne Byrne, Thorsten Langer, Antoinette am Zehnhoff-Dinnesen, Rahel Kuonen, Annette Weiss, Tomas Kepak, Jarmila Kruseova, Claire Berger, Gabriele Calaminus, Grit Sommer, Claudia E. Kuehni, on behalf of the PanCareLIFE Consortium

Published in: Journal of Cancer Survivorship

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Abstract

Purpose

Auditory complications are potential side effects from childhood cancer treatment. Yet, limited evidence exists about the impact of auditory complications—particularly tinnitus—on health-related quality of life (HRQoL) among childhood cancer survivors (CCS). We determined the prevalence of hearing loss and tinnitus in the European PanCareLIFE cohort of CCS and examined its effect on HRQoL.

Methods

We included CCS from four European countries who were diagnosed at age ≤ 18 years; survived ≥ 5 years; and aged 25–44 years at study. We assessed HRQoL (Short Form 36), hearing loss, and tinnitus using questionnaires. We used multivariable linear regression to examine associations between these two auditory complications and HRQoL adjusting for socio-demographic and clinical factors.

Results

Our study population consisted of 6,318 CCS (53% female; median age at cancer diagnosis 9 years interquartile range [IQR] 5–13 years) with median age at survey of 31 years (IQR 28–35 years). Prevalence was 7.5% (476/6,318; confidence interval [CI]: 6.9–8.2) for hearing loss and 7.6% (127/1,668; CI: 6.4–9.0) for tinnitus. CCS with hearing loss had impaired physical (coefficient [coef.] -4.3, CI: -7.0 to -1.6) and mental (coef. -3.2, CI: -5.5 to -0.8) HRQoL when compared with CCS with normal hearing. Tinnitus was associated with impaired physical (coef. -8.2, CI: -11.8 to -4.7) and mental (coef. -5.9, CI: -8.8 to -3.1) HRQoL.

Conclusion

We observed reduced HRQoL among CCS with hearing loss and tinnitus. Our findings indicate timely treatment of hearing loss and tinnitus may contribute to quality of life of survivors.

Implications for cancer survivors

CCS who experience auditory complications should be counseled about possible therapeutic and supportive measures during follow-up care.
Appendix
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Literature
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Metadata
Title
Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study
Authors
Sven Strebel
Katja Baust
Desiree Grabow
Julianne Byrne
Thorsten Langer
Antoinette am Zehnhoff-Dinnesen
Rahel Kuonen
Annette Weiss
Tomas Kepak
Jarmila Kruseova
Claire Berger
Gabriele Calaminus
Grit Sommer
Claudia E. Kuehni
on behalf of the PanCareLIFE Consortium
Publication date
22-09-2023
Publisher
Springer US
Keyword
Tinnitus
Published in
Journal of Cancer Survivorship
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-023-01456-4

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