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Endocrinology Thyroid Disease

Thyroid Disease

Muscular dystrophy or congenital hypothyroidism?

Thyroxine replacement led to marked clinical improvement and regression of hypertrophy in a young man with symptoms mimicking muscular dystrophy but diagnosed with Kocher-Debré-Semelaigne/Hoffmann syndrome.

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Editor's Choice

ICI-associated hypothyroidism, macular rash, and adrenal insufficiency

A complex case of hypothyroidism, macular rash, and adrenal insufficiency that developed in an older man several months after he received sintilimab for the treatment of esophageal carcinoma.

Effective treatment of pretibial myxedema with tofacitinib

A man with Graves disease and orbitopathy presented with bilateral pretibial myxedema. Oral tofacitinib was initiated after transient response to intralesional glucocorticoids‒edema and orbitopathy improved within 1 month.

Repurposing levothyroxine for MASLD and MASH?

Selective analogs of hepatic THRβ have recently been developed to treat metabolic dysfunction-associated steatohepatitis, but could levothyroxine and other thyroid hormone analogs offer an efficient, low-cost alternative?

IBI311 is a viable treatment for Chinese patients with active thyroid eye disease

Treatment of active thyroid eye disease with the insulin-like growth factor receptor inhibitor IBI311 results in clinically relevant improvements in proptosis outcomes in Chinese patients.

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Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Developed by: Springer Health+
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Case Studies

Muscular dystrophy or congenital hypothyroidism?

Thyroxine replacement led to marked clinical improvement and regression of hypertrophy in a young man with symptoms mimicking muscular dystrophy but diagnosed with Kocher-Debré-Semelaigne/Hoffmann syndrome.

ICI-associated hypothyroidism, macular rash, and adrenal insufficiency

A complex case of hypothyroidism, macular rash, and adrenal insufficiency that developed in an older man several months after he received sintilimab for the treatment of esophageal carcinoma.

Effective treatment of pretibial myxedema with tofacitinib

A man with Graves disease and orbitopathy presented with bilateral pretibial myxedema. Oral tofacitinib was initiated after transient response to intralesional glucocorticoids‒edema and orbitopathy improved within 1 month.

Current Reviews

Multimodal ultrasound assessment of ovarian reserve

Ovarian reserve represents the quantity and quality of a woman’s remaining oocytes and serves as a key indicator of reproductive potential. Accurate and non-invasive evaluation of ovarian reserve is essential for guiding fertility management …

Bidirectional Relationship Between Periodontal Disease and Thyroid Diseases

Oral health is believed to be linked to general health through a bidirectional relationship. Poor oral status can aggravate the course of systemic diseases, as well as systemic diseases or accompanying therapies may be reflected in oral …

Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis: an update

In recent years, the incidence of thyroid cancer has steadily increased. However, the detailed mechanisms of pathogenesis are still unclear. Therefore, a comprehensive understanding of the underlying carcinogenesis mechanisms of thyroid cancer is …

Clinical prognostic risk assessment of different pathological subtypes of papillary thyroid cancer: a systematic review and network meta-analysis

There are multiple pathologic subtypes of papillary thyroid carcinoma (PTC), each with distinct clinical prognoses. However, the available data on the clinicopathologic risks associated with several common PTC subtypes are controversial and …

CME & eLearning

Emerging biomarkers and comprehensive genomic profiling for NSCLC and thyroid cancer

  • NSCLC
  • On-demand Webinar

In this interactive webinar, experts discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations. 

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Developed by: Springer Health+

Paediatric endocrinology (Link opens in a new window)

Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver news, cases and expert reviews covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.

Supported by:
  • Merck Healthcare KGaA, Darmstadt, Germany
Developed by: Springer Health+ IME

Further Reading

Multimodal ultrasound assessment of ovarian reserve

Ovarian reserve represents the quantity and quality of a woman’s remaining oocytes and serves as a key indicator of reproductive potential. Accurate and non-invasive evaluation of ovarian reserve is essential for guiding fertility management …

TC check: a web app for thyroid cancer recurrence prediction using explainable machine learning

Thyroid cancer (TC) is one of the most common endocrine malignancies (Jin et al. 2025 ; Maleki et al. 2023 ; Pizzato et al. 2022 ). In 2020, it ranked ninth among all cancers globally (Nguyen et al. 2025 ; Zhanghuang et al. 2024 ). In 2019, TC …

Immunomodulatory effects of lenvatinib in patients with advanced thyroid cancer

Lenvatinib is a multitargeted tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFR) 1–3, fibroblast growth factor receptors (FGFR) 1–4, platelet-derived growth factor receptor α (PDGFR α ), RET, and KIT [ 1 ].

Impact of comorbidities on treatment management and prognosis in patients with anaplastic thyroid cancer (ATC)

To evaluate the impact of comorbidities on treatment allocation and prognosis in anaplastic thyroid cancer, 137 patients from 10 German tertiary cancer centers treated with radiotherapy between 2001 and 2020 were analyzed. Four validated …

Image Credits
Clinical images of hypertrophy/© (M) 2025, Subhajit Roy et al, Acta Neurol Belg, under exclusive licence to Belgian Neurological Society, ECG in a patient with hypothyroidism, macular rash, and adrenal crisis following ICI treatment/© 2025, Zhong-qing Mou et al, BMC Endocr Disord, Pretibial myxoedema before and after treatment with tofacitinib/© 2025, Chen-xi Zhao et al, Thyroid Res, Question mark made of pills/© Nadzeya / stock.adobe.com, Ophthalmologist pointing to a model of eye anatomy/© Drazen Zigic / Getty Images / iStock (symbolic image with models), Illustration of the parathyroid glands /© Kateryna Kon / Science Photo Library / Getty Images, Pregnant woman at a medical appointment/© Phushutter / stock.adobe.com (symbolic image with models), Woman holding her hand to her throat/© Olga Pankova / Moment / Getty Images (symbolic image with model), Search for disease or pathology of the thyroid gland/© burdun / stock.adobe.com, Post-surgical scar on woman's neck/© catinsyrup / Getty Images / iStock, Genetic code/© Springer Healthcare, medwireNewsFocus: Pediatric endocrinology teaser