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European Journal of Nuclear Medicine and Molecular Imaging
Published in:

20-05-2024 | Thyroid Cancer | Image of the Month

Successful radioiodine redifferentiation with selpercatinib in RET fusion-positive papillary thyroid carcinoma

Authors: Daniela Weiler, MD, Maria del Sol Pérez Lago, MD

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2024

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Excerpt

Radioiodine- refractory thyroid cancer patients have a worse prognosis. If specific driver mutations like BRAF, RET, NTRK are identified, mutation specific kinase inhibitors should be preferred over multikinase inhibitors [1]. In selected cases, specific kinase inhibitors restore radioiodine sensitivity enabling further radioiodine treatment (RIT) [2‐5]. …
Literature
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Werner RA, Sahyeli C, Hänscheid H, et al. Successful combination of selpercatinib and radioiodine after pretherapeutic dose estimation in RET-altered thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2023;50:1833–18346.CrossRefPubMed
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Metadata
Title
Successful radioiodine redifferentiation with selpercatinib in RET fusion-positive papillary thyroid carcinoma
Authors
Daniela Weiler, MD
Maria del Sol Pérez Lago, MD
Publication date
20-05-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2024
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-024-06747-1

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