Skip to main content

Advanced Search

Projected result for your current search:: 0

Search Operators:

You can use operators in your search query to narrow down your results even more. Click on the search operator to see an explanation of how it works.
Finds documents with exactly this word group, in exactly this word order and spelling (e.g. "employer branding").
Finds documents with both search terms (e.g. sales AND bonus).
Finds documents with one or the other search term (e.g. porsche OR volkswagen).
Finds documents with all search terms. Blank space is understood as AND (e.g. man robot production).
Finds documents with no appearance of the word behind NOT (e.g. ford NOT "harrison ford").
Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g. COUNT(gear)>8).
Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g. NEAR(recruit, professionals, 20)).
Finds documents with the search term in word versions or composites. The asterisk * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g. lightweight*, *lightweight, *lightweight*).
Finds documents with the search term in different spellings. "?" allows only one character (e.g. organi?ation).
Special characters are understood as AND (e.g. Miller Bros. & Sons).
 Log in
Top
European Archives of Oto-Rhino-Laryngology

Role of nutritional (PNI, CONUT) and inflammatory indices (SII) in predicting lymph node metastasis and prognosis of thyroid cancer: a systematic review and meta-analysis

Authors
Yi Liu
Rong Xiao
Published in
European Archives of Oto-Rhino-Laryngology

Abstract

Purpose

Markers reflecting systemic inflammation and nutritional condition are now often applied in predicting cancer outcomes, yet their role in thyroid malignancies has not been clearly established. We reviewed the evidence in the literature on the role of Prognostic Nutritional Index (PNI), Controlling Nutritional Status Score (CONUT), and Systemic Immune-Inflammation Index (SII) in predicting lymph node metastasis (LNM), overall survival (OS), and disease-free survival (DFS) in thyroid cancer.

Methods

Two reviewers searched CENTRAL, Embase, PubMed, and Scopus databases till 24th August 2025 for relevant publications. A random-effects meta-analysis was conducted.

Results

Thirteen studies were eligible. Combined results demonstrated that elevated SII was slightly but significantly correlated with increased risk of LNM (HR: 1.00; 95% CI: 1.00–1.01; I² = 93%). Results failed to change in the sensitivity analysis. Subgroup analysis based on location and histology indicated non-significant results while meta-regression did not identify any significant moderators. Pooled analysis indicated no significant association between low PNI and DFS (HR: 1.45 95% CI: 0.97, 2.18 I2 = 80%) and LNM (HR: 1.31 95% CI: 0.89, 1.92 I2 = 73%) in thyroid cancer patients. Meta-analysis also showed that high CONUT was associated with a tendency of worse DFS in thyroid cancer, but results were non-significant (HR: 3.25 95% CI: 0.99, 10.69 I2 = 86%). However, meta-analysis showed that high CONUT was significantly associated with worse OS (HR: 9.67 95% CI: 1.90, 49.25 I2 = 61%).

Conclusions

Limited data suggest that high SII may be marginally associated with increased risk of LNM in thyroid cancer, the clinical significance of which is questionable. PNI was not found to be associated with LNM or DFS in thyroid cancer patients. High CONUT was associated with poor OS and a non-significant tendency for worse DFS in thyroid cancer.
Title
Role of nutritional (PNI, CONUT) and inflammatory indices (SII) in predicting lymph node metastasis and prognosis of thyroid cancer: a systematic review and meta-analysis
Authors
Yi Liu
Rong Xiao
Publication date
03-02-2026
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-025-09976-8
This content is only visible if you are logged in and have the appropriate permissions.
This content is only visible if you are logged in and have the appropriate permissions.