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Open Access 02-12-2024 | Thyroid Cancer | Case Report

A case report and literature review of rare isolated metastatic papillary thyroid carcinoma in the orbit

Authors: Behzad Khademi, Zahra Zia

Published in: Thyroid Research | Issue 1/2024

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Abstract

Purpose

Orbital metastasis secondary to thyroid carcinoma is an exceedingly rare occurrence. In this case report, we present a rare isolated orbital metastasis of papillary thyroid carcinoma (PTC).

Methods

A case report and literature review study.

Result

A 55-year-old female, who presented with right-sided exophthalmos persisting for seven months and a week-long history of decreased visual acuity. Orbital computed tomography (CT) revealed a solid, isolated, well-circumscribed mass confined to the right intra-conal orbital cavity. Surgical excision via lateral orbitotomy confirmed the diagnosis of metastatic PTC.

Conclusion

Most cases reported in the literature have identified orbital masses concurrently with the initial diagnosis of thyroid carcinoma. In contrast, our patient exhibited ocular symptoms following a prolonged interval after normal post ablative iodine imaging, highlighting a significant delay in metastatic presentation. Moreover, the solid and well-defined nature of the metastatic orbital mass, confined solely to the orbital cavity without evidence of bony destruction, muscle involvement or intracranial extension in this patient, constitutes a distinctive clinical feature rarely documented in existing case reports.
Literature
1.
go back to reference Keshavarzi A, Alaei-Shahmiri F, Fallahi B, Emami Z. Predictors of response to radioactive iodine therapy in intermediate and high risk patients with papillary thyroid carcinoma. BMC Endocr Disord. 2024;24(1):112.CrossRefPubMedCentralPubMed Keshavarzi A, Alaei-Shahmiri F, Fallahi B, Emami Z. Predictors of response to radioactive iodine therapy in intermediate and high risk patients with papillary thyroid carcinoma. BMC Endocr Disord. 2024;24(1):112.CrossRefPubMedCentralPubMed
2.
go back to reference Sapuppo G, Martorana F, Tirrò E, Le Moli R, Masucci R, Baldeschi L, Spatola C, Belfiore A, Vigneri P, Pellegriti G. Orbital metastasis from thyroid cancer: a case report and review of the literature. Ann Palliat Med. 2022;11(10):3346355–3343355.CrossRef Sapuppo G, Martorana F, Tirrò E, Le Moli R, Masucci R, Baldeschi L, Spatola C, Belfiore A, Vigneri P, Pellegriti G. Orbital metastasis from thyroid cancer: a case report and review of the literature. Ann Palliat Med. 2022;11(10):3346355–3343355.CrossRef
3.
go back to reference Jobran R, Baloch Z, Aviles V, Rosato E, Schwartz S, LiVolsi V. Tall cell papillary carcinoma of the thyroid: metastatic to the pancreas. Thyroid. 2000;10(2):185–7.CrossRefPubMed Jobran R, Baloch Z, Aviles V, Rosato E, Schwartz S, LiVolsi V. Tall cell papillary carcinoma of the thyroid: metastatic to the pancreas. Thyroid. 2000;10(2):185–7.CrossRefPubMed
4.
go back to reference Clark JR, Lai P, Hall F, Borglund A, Eski S, Freeman JL. Variables predicting distant metastases in thyroid cancer. Laryngoscope. 2005;115(4):661–7.CrossRefPubMed Clark JR, Lai P, Hall F, Borglund A, Eski S, Freeman JL. Variables predicting distant metastases in thyroid cancer. Laryngoscope. 2005;115(4):661–7.CrossRefPubMed
5.
go back to reference Daumerie C, De Potter P, Godfraind C, Rahier J, Jamar F, Squifflet J-P. Orbital metastasis as primary manifestation of thyroid carcinoma. Thyroid. 2000;10(2):189–92.CrossRefPubMed Daumerie C, De Potter P, Godfraind C, Rahier J, Jamar F, Squifflet J-P. Orbital metastasis as primary manifestation of thyroid carcinoma. Thyroid. 2000;10(2):189–92.CrossRefPubMed
6.
go back to reference Boughattas S, Chatti K, Degdegui M, Bouslama Z, ElAouni C. Uncommon case of orbital metastasis secondary to papillary thyroid carcinoma. Thyroid. 2005;15(11):1311–2.CrossRefPubMed Boughattas S, Chatti K, Degdegui M, Bouslama Z, ElAouni C. Uncommon case of orbital metastasis secondary to papillary thyroid carcinoma. Thyroid. 2005;15(11):1311–2.CrossRefPubMed
7.
go back to reference Yethadka R, Vijayakumar A, Kumar KS. Proptosis from metastatic thyroid carcinoma: case report and review. Ophthalmol Res Int J. 2014;2:18–23.CrossRef Yethadka R, Vijayakumar A, Kumar KS. Proptosis from metastatic thyroid carcinoma: case report and review. Ophthalmol Res Int J. 2014;2:18–23.CrossRef
8.
go back to reference Bagheri A, Shahraki K, Arabi A, Kashkouli MB. Normal exophthalmometry values in iranian population: a meta-analysis. J Ophthalmic Vis Res. 2021;16(3):470–7.PubMedCentralPubMed Bagheri A, Shahraki K, Arabi A, Kashkouli MB. Normal exophthalmometry values in iranian population: a meta-analysis. J Ophthalmic Vis Res. 2021;16(3):470–7.PubMedCentralPubMed
9.
go back to reference Bernstein-Lipschitz L, Lahav M, Chen V, Gutman I, Gal R, Lipschitz M. Metastatic thyroid carcinoma masquerading as lacrimal gland tumor. Graefes Arch Clin Exp Ophthalmol. 1990;228(1):112–5.CrossRefPubMed Bernstein-Lipschitz L, Lahav M, Chen V, Gutman I, Gal R, Lipschitz M. Metastatic thyroid carcinoma masquerading as lacrimal gland tumor. Graefes Arch Clin Exp Ophthalmol. 1990;228(1):112–5.CrossRefPubMed
10.
go back to reference Font RL, Ferry AP. Carcinoma metastatic to the eye and orbit. III. A clinicopathologic study of 28 cases metastatic to the orbit. Cancer. 1976;38(3):1326–35.CrossRefPubMed Font RL, Ferry AP. Carcinoma metastatic to the eye and orbit. III. A clinicopathologic study of 28 cases metastatic to the orbit. Cancer. 1976;38(3):1326–35.CrossRefPubMed
11.
go back to reference Shyla P, Nair RM, Somanathan T. Rare case of orbital tumor. Indian J Otolaryngol. 2007;59(2):174–5.CrossRef Shyla P, Nair RM, Somanathan T. Rare case of orbital tumor. Indian J Otolaryngol. 2007;59(2):174–5.CrossRef
12.
go back to reference Rocha Filho FD, Lima GG, Ferreira FV, Lima MG, Hissa MN. Orbital metastasis as primary clinical manifestation of thyroid carcinoma: case report and literature review. ABE&M. 2008;52:1497–500. Rocha Filho FD, Lima GG, Ferreira FV, Lima MG, Hissa MN. Orbital metastasis as primary clinical manifestation of thyroid carcinoma: case report and literature review. ABE&M. 2008;52:1497–500.
13.
go back to reference Repanos C, Ho YM, Bird K, Coman S, Coman WB, Wallwork B. Metastatic papillary thyroid carcinoma involving orbit: a case report and review. ANZ J Surg. 2011;81(5):375–6.CrossRefPubMed Repanos C, Ho YM, Bird K, Coman S, Coman WB, Wallwork B. Metastatic papillary thyroid carcinoma involving orbit: a case report and review. ANZ J Surg. 2011;81(5):375–6.CrossRefPubMed
14.
go back to reference Besic N, Luznik Z. Choroidal and orbital metastases from thyroid cancer. Thyroid. 2013;23(5):543–51.CrossRefPubMed Besic N, Luznik Z. Choroidal and orbital metastases from thyroid cancer. Thyroid. 2013;23(5):543–51.CrossRefPubMed
15.
go back to reference Mahyuddin M, Theresia K, Anggraini N, Subekti HI. Orbital metastases as the initial clinical manifestation of thyroid carcinoma: a case series. Oman J Ophthalmol. 2022;15(1):85–8.CrossRefPubMedCentralPubMed Mahyuddin M, Theresia K, Anggraini N, Subekti HI. Orbital metastases as the initial clinical manifestation of thyroid carcinoma: a case series. Oman J Ophthalmol. 2022;15(1):85–8.CrossRefPubMedCentralPubMed
16.
go back to reference Pagsisihan DA, Aguilar AHI, Maningat MPDD. Orbital metastasis as initial manifestation of a widespread papillary thyroid microcarcinoma. Case Rep. 2015;2015:bcr2014208870. Pagsisihan DA, Aguilar AHI, Maningat MPDD. Orbital metastasis as initial manifestation of a widespread papillary thyroid microcarcinoma. Case Rep. 2015;2015:bcr2014208870.
17.
go back to reference Lam AK-Y, Lo C-Y, Lam KS-L. Papillary carcinoma of thyroid: a 30-yr clinicopathological review of the histological variants. Endocr. 2005;16(4):323–30. Lam AK-Y, Lo C-Y, Lam KS-L. Papillary carcinoma of thyroid: a 30-yr clinicopathological review of the histological variants. Endocr. 2005;16(4):323–30.
18.
go back to reference El Bakraoui K, El Morabit B. Orbital metastasis from triple-negative breast cancer: case report and literature review. Case Rep Oncol. 2020;13(2):1042–6.CrossRefPubMedCentralPubMed El Bakraoui K, El Morabit B. Orbital metastasis from triple-negative breast cancer: case report and literature review. Case Rep Oncol. 2020;13(2):1042–6.CrossRefPubMedCentralPubMed
19.
go back to reference Shields J, Shields C, Brotman H, Carvalho C, Perez N Jr, Eagle RC Jr. Cancer metastatic to the orbit: the 2000 Robert M. Curts lecture. Ophthalmic Plast Reconstr Surg. 2001;17:346–54.CrossRefPubMed Shields J, Shields C, Brotman H, Carvalho C, Perez N Jr, Eagle RC Jr. Cancer metastatic to the orbit: the 2000 Robert M. Curts lecture. Ophthalmic Plast Reconstr Surg. 2001;17:346–54.CrossRefPubMed
20.
go back to reference Bidari-Zerehpoosh F, Sharifi G, Zahedifard S, Soleimantabar H, Ebrahimzadeh K, Aghakhani A. Bilateral Orbital Metastasis of Follicular Thyroid Carcinoma: a Rare Case Report. Iran J Pathol. 2014;9(3):229–33. Bidari-Zerehpoosh F, Sharifi G, Zahedifard S, Soleimantabar H, Ebrahimzadeh K, Aghakhani A. Bilateral Orbital Metastasis of Follicular Thyroid Carcinoma: a Rare Case Report. Iran J Pathol. 2014;9(3):229–33.
21.
go back to reference Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133.CrossRefPubMedCentralPubMed Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133.CrossRefPubMedCentralPubMed
22.
go back to reference Ritland J, Eide N, Walaas L, Høie J. Fine-needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma. Acta Ophthalmol. 1999;77(5):594–6.CrossRef Ritland J, Eide N, Walaas L, Høie J. Fine-needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma. Acta Ophthalmol. 1999;77(5):594–6.CrossRef
Metadata
Title
A case report and literature review of rare isolated metastatic papillary thyroid carcinoma in the orbit
Authors
Behzad Khademi
Zahra Zia
Publication date
02-12-2024
Publisher
BioMed Central
Published in
Thyroid Research / Issue 1/2024
Electronic ISSN: 1756-6614
DOI
https://doi.org/10.1186/s13044-024-00216-5

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