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ICI-induced fulminant type 1 diabetes

A case of fulminant type 1 diabetes in a woman on tislelizumab for lung adenocarcinoma highlights the need for proactive monitoring of fasting glucose, HbA1c, and islet function in people given an immune checkpoint inhibitor.

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Editor's Choice

Add-on FMT shows promise in multiple cancers

Three trials point to the potential of fecal microbiota transplantation to enhance the efficacy of immune checkpoint inhibitor-based therapy in people with cancer.

Who benefits from treatment intensification in NSCLC?

  • Open Access
  • NSCLC
  • Review

Recent trials have shown survival benefits of intensified regimens in EGFR-mutant NSCLC, but they come at the cost of increased toxicity and treatment burden. So which patients should receive upfront intensification?

Lung cancer in nonsmoking women

Familiarize yourself with the current evidence on risk factors, molecular pathology, and treatment strategies for lung cancer in nonsmoking women, and understand the critical role of gender susceptibility.

Lung cancer presenting with arginine vasopressin deficiency

A complicated case in which a patient admitted with polyuria and polydipsia was diagnosed with arginine vasopressin deficiency, which was ultimately found to be a manifestation of lung cancer.

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Case simulations: Biomarker-driven management of NSCLC (Link opens in a new window)

Do you want to assess your biomarker testing skills and management decisions? Use these simulation-based case studies based on realistic NSCLC scenarios to do so in a practical and secure environment.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window

Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Watch now
Video

Case Studies

ICI-induced fulminant type 1 diabetes

A case of fulminant type 1 diabetes in a woman on tislelizumab for lung adenocarcinoma highlights the need for proactive monitoring of fasting glucose, HbA1c, and islet function in people given an immune checkpoint inhibitor.

Lung cancer presenting with arginine vasopressin deficiency

A complicated case in which a patient admitted with polyuria and polydipsia was diagnosed with arginine vasopressin deficiency, which was ultimately found to be a manifestation of lung cancer.

Combined SCLC: a difficult-to-treat variant

  • Open Access
  • SCLC
  • Case Study

An extremely rare case of combined small-cell lung cancer with adenocarcinoma. Such variants can be difficult to diagnose and treat. How would you manage this patient?

Episode 7: A deep dive into ADAURA

The ADAURA trial has, as of this year, demonstrated an overall survival benefit with the adjuvant use of osimertinib in people with resectable NSCLC. 

We take an in-depth look at the study with Dr. Luis Paz-Ares, who outlines the study findings, discusses the clinical implications, and addresses the pertinent questions raised by the trial.

Dr. Luis Paz-Ares
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Podcast

Current Reviews

Body mass index (BMI) and risk of lung cancer: a systematic review and meta-analysis of studies using directly measured and genetically proxied measures of BMI

Lung cancer is the leading cause of cancer death in the United States (US) and globally [ 1 – 3 ]. Many risk factors for lung cancer have been identified, with cigarette smoking being the predominant cause [ 4 , 5 ]. Cigarette smoking causes 85–90% …

Thymic epithelial tumors at the crossroads of immunity, autoimmunity, and immunotherapy

Thymic epithelial tumors (TETs) sit at a unique intersection of cancer, central tolerance, and autoimmunity. These tumors arise in the thymus, an immune-rich organ responsible for T-cell education, and despite their low tumor mutational burden …

Salvage surgery after epidermal growth factor receptor tyrosine kinase inhibitor therapy for non-small cell lung cancer: a focused narrative review

This article provides a focused narrative review of salvage surgery after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for non-small cell lung cancer (NSCLC). It highlights its conceptual differences from salvage …

Reprogramming resistance in advanced lung cancer: epigenetic modulation to restore therapeutic vulnerability

Lung cancer is the most prevalent cancer and cause of death; most patients present themselves at an advanced stage and continuously acquire resistance to targeted agents, antibody–drug conjugates, chemotherapy, and immune checkpoint inhibitors. In …

CME & eLearning

Video

Emerging biomarkers and comprehensive genomic profiling for NSCLC and thyroid cancer

  • NSCLC
  • On-demand Webinar

In this interactive webinar, experts discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations. 

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company

Biomarker-driven management of NSCLC (Link opens in a new window)

  • NSCLC
  • Multiformat Program

0.75 AMA PRA Category 1 Credit(s)

Expert-led, multiformat program which addresses the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Use the guidance on integrating shared decision making into clinical practice, drawing on insights from a patient on how best to communicate.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.

Further Reading

HIF-1α siRNA Enhances the Efficacy of Erlotinib in Non-small Cell Lung Cancer: A Novel Strategy to Reverse Hypoxia-Induced Drug Resistance

  • Open Access
  • NSCLC
  • Original Research Article

Non-small cell lung cancer (NSCLC), accounting for 85% of all lung cancer cases, continues to pose a severe global health challenge [ 1 ]. According to the 2022 Global Cancer Statistics [ 2 ], lung cancer remains the leading cause of cancer …

Catgut implantation at acupoints improves anti-PD-1 inhibitor efficacy in lung cancer by inducing immune responses and remodeling the tumor microenvironment

While anti-programmed death-1 (anti-PD-1) therapy has revolutionized lung cancer treatment, its efficacy remains limited by an immunosuppressive tumor microenvironment (TME). We therefore investigated whether combining anti-PD-1 inhibitor with …

An innovative treatment for lung cancer using gene-engineered human-induced pluripotent stem cell-derived natural killer cells

Various therapeutic approaches have been developed for lung cancer, including chemotherapy, radiation therapy, and immune checkpoint inhibitors. However, these approaches, including chimeric antigen receptor (CAR)-T cell therapy, have shown …

Immune checkpoint inhibitor–related myocarditis in patients with thymic epithelial tumors: a retrospective cohort analysis

Thymic epithelial tumors (TET), including thymomas and thymic carcinomas, are rare tumors, and for recurrent or metastatic TET, systemic treatment options are limited [ 1 ]. Immune checkpoint inhibitors (ICI) have progressively emerged as a key …

Related topics

Bacterial contributions to oncogenesis

From the mechanistic contributions of pathogenic bacteria to tumor initiation, to the role dysbiosis plays in influencing systemic cancer behavior, understand the impact bacteria has as a driver of cancer development.

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Image Credits
Enhanced chest CT showing a solid lesion in the lower left lung/© 2026, Yuanzhen Feng et al, J Med Case Reports, Artistic rendering of fecal microbiota transplantation pills/© mbruxelle / Stock.adobe.com, Yellow question mark in front of a row of wooden figures/© Abu Hanifah / Getty Images / iStock, Woman consulting with doctor/© Wesley / peopleimages.com / Stock.adobe.com (symbolic image with models), CT scan of lung cancer patient presenting with arginine vasopressin deficiency/© 2025, Maryam Alsadat Tabatabaei et al, J Med Case Reports, Biomarker-driven management of NSCLC logo/© Springer Health+ IME, Fast food and drinks/© hin255 / stock.adobe.com, Syringe and vial/© Ake Ngiamsanguan / Getty Images / iStock, Genetic code/© Springer Healthcare, Immunohistochemistry of patient with combined SCLC/© 2025, Xiao Wu et al, J Cancer Res Clin Oncol, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Malignant cancer cells/© koto_feja / Getty Images / iStock, Coronary angiography demonstrating an ectatic vessel arising from the left circumflex artery supplying a lung mass/© 2025, Muath A. Baniowda et al, BMC Cardiovascular Disorders, Syringe and multicolored pills on red background/© VlaDee / Getty Images / iStock