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The Relationship of Type 2 Diabetes, Oral Diabetes Medications, and Insulin Therapy to Risk for Breast Cancer

  • 01-03-2014
  • Cancer (MF Leitzmann, Section Editor)
Published in:

Abstract

The interaction between type 2 diabetes mellitus (DM) and breast cancer has become an important focus of research. DM appears to increase the risk of breast cancer and to negatively impact on breast cancer prognosis and screening. While evidence suggests that DM medications can modulate the relationship between DM and cancer, relatively few studies have specifically examined the association between medication exposure and breast cancer risk. Current evidence suggests that insulin plays a central role in the relationship between DM and breast cancer, but that other shared risk factors such as oxidative stress and inflammation may also contribute significantly. Further research is necessary to better understand the mechanisms underlying the relationship between DM and breast cancer and to fully realize the modulating effects of medication exposure.
Title
The Relationship of Type 2 Diabetes, Oral Diabetes Medications, and Insulin Therapy to Risk for Breast Cancer
Authors
Trista J. Stankowski-Drengler
Rachel V. Stankowski
Jessica M. Engel
Adedayo A. Onitilo
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 1/2014
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-013-0066-y
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