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Indian Journal of Hematology and Blood Transfusion

13-11-2024 | Thalassemia | SHORT COMMUNICATION

Identification of Antibody to Low-Frequency Antigen in Thalassemia: Non-specific Allo Adsorption Method

Authors: Kriti Batni, Seema Dua, Archit Pandharipande, Nita Radhakrishnan, Anupa Pokhrel, Satyam Arora

Published in: Indian Journal of Hematology and Blood Transfusion

Abstract

Low-incidence antigens are known to occur in less than 1% of individuals in most populations. Alloantibodies against low-frequency antigens pose a risk of potential hemolytic transfusion reactions and hemolytic disease in fetuses and newborns. We describe a technique of “Nonspecific alloadsorption” to identify a suspected antibody to a low-frequency antigen in the presence of an interfering autoantibody. A 15-year-old thalassaemic reported to our blood bank with an inability to find compatible blood units. There was a presence of an allo-antibody with auto-antibody. We attempted a “non-specific allo adsorption” for identifying an interfering allo-antibody against a low-frequency antigen. Our case report highlights that understanding the basic antigenic frequencies of various antigens can play an important role in antibody identification. It is always important to exclude alloantibody when autoantibody or AIHA scenarios are presented in thalassemia patients for safe transfusions.

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Title: Identification of Antibody to Low-Frequency Antigen in Thalassemia: Non-specific Allo Adsorption Method
Authors: Kriti Batni
Seema Dua
Archit Pandharipande
Nita Radhakrishnan
Anupa Pokhrel
Satyam Arora
Publication date: 13-11-2024
Publisher: Springer India
Keyword: Thalassemia
Published in: Indian Journal of Hematology and Blood Transfusion
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-024-01925-5

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Identification of Antibody to Low-Frequency Antigen in Thalassemia: Non-specific Allo Adsorption Method

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Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma