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World Journal of Pediatrics

Open Access 22-09-2023 | Tetralogy of Fallot | Original Article

Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice

Authors: Si-Yu Ma, Yu-Ting Liu, Yue-Shuang Cun, Qiang Wang, Ming-Cui Fu, Ke-De Wu, Xin-Yu Cai, Shu-Ting Cheng, Nishant Patel, Min Da, Liang Hu, Zhuoga Deqin, Xue-Jun Kang, Ming Yang, Xu-Ming Mo

Published in: World Journal of Pediatrics

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Abstract

Background

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Children with TOF would be confronted with neurological impairment across their lifetime. Our study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with TOF.

Methods

We used mass spectrometry (MS) technology to assess the levels of serum metabolites, Wechsler preschool and primary scale of intelligence-Fourth edition (WPPSI-IV) index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging (MRI) to detect cortical morphological changes.

Results

Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal index. Meanwhile, preoperative SpO2 was negatively correlated with levels of serum cortisone after adjusting for all covariates. Furthermore, after intervening levels of cortisone in chronic hypoxic model mice, total brain volumes were reduced at both postnatal (P) 11.5 and P30 days.

Conclusions

Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with TOF. Our study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.
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Metadata
Title
Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice
Authors
Si-Yu Ma
Yu-Ting Liu
Yue-Shuang Cun
Qiang Wang
Ming-Cui Fu
Ke-De Wu
Xin-Yu Cai
Shu-Ting Cheng
Nishant Patel
Min Da
Liang Hu
Zhuoga Deqin
Xue-Jun Kang
Ming Yang
Xu-Ming Mo
Publication date
22-09-2023
Publisher
Springer Nature Singapore
Published in
World Journal of Pediatrics
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-023-00754-2