Skip to main content
Top
Published in: Hormones 1/2024

20-11-2023 | Testosterone | Original Article

The effect of testosterone level on metabolic syndrome: a cross-sectional study

Authors: Sercan Gucenmez, Pinar Yildiz, Omer Donderici, Rustu Serter

Published in: Hormones | Issue 1/2024

Login to get access

Abstract

Background

Metabolic syndrome (MS) may reduce circulating testosterone and, at the same time, low testosterone levels may lead to MS. Thus, identifying problems regarding sex hormones and examining their effects on the pathogenesis of MS is important to prevent serious complications of the condition, such as diabetes or cardiovascular diseases.

Aims

This study aimed to investigate the correlations between MS-related parameters and androgen levels.

Methods

A total of 108 males [median age 48.5 years (min/max = 21/77 years)] were included in the study. Blood pressure and anthropometric measurements (body mass index, waist circumference, hip circumference, thigh circumference, neck circumference, and length of index and ring finger) were performed. Biochemical analysis was assessed. Additionally, total testosterone, free testosterone, and sex hormone binding globulin levels were investigated.

Results

Weak negative correlations were observed between testosterone levels and several anthropometric measures/glucose metabolisms (p < 0.05). The highest correlation was between total testosterone levels and body mass index (rho= −0.390, p < 0.001)

Conclusion

According to our results, controlling weight, one of the preventable risk factors, can have a positive effect on testosterone levels and, therefore, on the cardiovascular system through different mechanisms.
Literature
16.
go back to reference Kaplan SA, Meehan AG, Shah A (2006) The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men? J Urol 176(4 Pt 1):1524–1527CrossRefPubMed Kaplan SA, Meehan AG, Shah A (2006) The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men? J Urol 176(4 Pt 1):1524–1527CrossRefPubMed
17.
go back to reference Katznelson L, Rosenthal DI, Rosol MS, Anderson EJ, Hayden DL, Schoenfeld DA, Klibanski A (1998) Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism. AJR Am J Roentgenol 170:423–427CrossRefPubMed Katznelson L, Rosenthal DI, Rosol MS, Anderson EJ, Hayden DL, Schoenfeld DA, Klibanski A (1998) Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism. AJR Am J Roentgenol 170:423–427CrossRefPubMed
30.
go back to reference de Rekeneire N, Peila R, Ding J, Colbert LH, Visser M, Shorr RI, Kritchevsky SB, Kuller LH, Strotmeyer ES, Schwartz AV, Vellas B, Harris TB (2006) Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study. Diabetes Care 29(8):1902–1908. https://doi.org/10.2337/dc05-2327CrossRefPubMed de Rekeneire N, Peila R, Ding J, Colbert LH, Visser M, Shorr RI, Kritchevsky SB, Kuller LH, Strotmeyer ES, Schwartz AV, Vellas B, Harris TB (2006) Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study. Diabetes Care 29(8):1902–1908. https://​doi.​org/​10.​2337/​dc05-2327CrossRefPubMed
39.
go back to reference Bengtsson C, Lapidus L, Stendahl C, Waldenström J (1988) Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. Acta Med Scand 224(6):549–555CrossRefPubMed Bengtsson C, Lapidus L, Stendahl C, Waldenström J (1988) Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. Acta Med Scand 224(6):549–555CrossRefPubMed
42.
46.
go back to reference Tang YJ, Lee WJ, Chen YT, Liu PH, Lee MC, Sheu WH (2007) Serum testosterone level and related metabolic factors in men over 70 years old. J Endocrinol Invest 30(6):451–458CrossRefPubMed Tang YJ, Lee WJ, Chen YT, Liu PH, Lee MC, Sheu WH (2007) Serum testosterone level and related metabolic factors in men over 70 years old. J Endocrinol Invest 30(6):451–458CrossRefPubMed
47.
go back to reference Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB (2006) Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 91(3):843–850. https://doi.org/10.1210/jc.2005-1326CrossRefPubMed Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB (2006) Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 91(3):843–850. https://​doi.​org/​10.​1210/​jc.​2005-1326CrossRefPubMed
Metadata
Title
The effect of testosterone level on metabolic syndrome: a cross-sectional study
Authors
Sercan Gucenmez
Pinar Yildiz
Omer Donderici
Rustu Serter
Publication date
20-11-2023
Publisher
Springer International Publishing
Published in
Hormones / Issue 1/2024
Print ISSN: 1109-3099
Electronic ISSN: 2520-8721
DOI
https://doi.org/10.1007/s42000-023-00507-w

Other articles of this Issue 1/2024

Hormones 1/2024 Go to the issue