Does the hemodialysis program affect the testosterone serum level in patients with end-stage renal disease?
- 29-10-2024
- Testosterone
- Urology – Original Paper
Published in:
- Authors
- Mahmoud Mustafa
- Imad Khaznah
- Donya Hrezat
- Lama Abu Obaida
- Amir Aghbar
- Published in
- International Urology and Nephrology | Issue 3/2025
Abstract
Purpose
This study aimed to evaluate the effect of high flux membrane hemodialysis on total serum testosterone (TST) levels in male patients with end-stage renal disease (ESRD).
Methods
The study included 60 male ESRD patients with a mean age of 54.02 ± 13.40 years, undergoing a standard hemodialysis program et al. Najah National University Hospital. All patients underwent three weekly sessions of four hours each using high flux membrane hemodialysis. TST and hematocrit (Hct) levels were measured before and after hemodialysis. Patients with prostate cancer, liver insufficiency, prior prostate surgery, or those on androgen therapy were excluded. The study assessed changes in TST and Hct levels and their correlation.
Results
Post-dialysis, there was a significant increase in serum testosterone levels from 3.13 ± 1.44 ng/ml to 4.17 ± 2.04 ng/ml (r = 0.78, p = 0.001). Hematocrit levels also rose significantly from 32.31% ± 3.90% to 35.27% ± 4.89% (r = 0.754, p = 0.001). The percentage change in TST and Hct levels was 35 ± 0.33% and 9 ± 0.1%, respectively, with a correlation between these changes (r = 0.277, p = 0.032).
Conclusion
High flux membrane dialysis did not filter testosterone molecules, and the significant increase in TST levels post-dialysis is likely due to hemoconcentration. Since many patients had low or borderline TST levels before dialysis, androgen supplementation may offer clinical benefits.
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- Title
- Does the hemodialysis program affect the testosterone serum level in patients with end-stage renal disease?
- Authors
-
Mahmoud Mustafa
Imad Khaznah
Donya Hrezat
Lama Abu Obaida
Amir Aghbar
- Publication date
- 29-10-2024
- Publisher
- Springer Netherlands
- Keywords
-
Testosterone
Androgens
Hypogonadism - Published in
-
International Urology and Nephrology / Issue 3/2025
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584 - DOI
- https://doi.org/10.1007/s11255-024-04265-5
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