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26-06-2023 | Original Article

Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability

Authors: Kevin de Matos, Claire Cury, Lydia Chougar, Lachlan T. Strike, Thibault Rolland, Maximilien Riche, Lisa Hemforth, Alexandre Martin, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Vincent Frouin, Meritxell Bach Cuadra, Olivier Colliot, Baptiste Couvy-Duchesne, IMAGEN Consortium

Published in: Brain Structure and Function | Issue 6/2023

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Abstract

The temporo-basal region of the human brain is composed of the collateral, the occipito-temporal, and the rhinal sulci. We manually rated (using a novel protocol) the connections between rhinal/collateral (RS-CS), collateral/occipito-temporal (CS-OTS) and rhinal/occipito-temporal (RS-OTS) sulci, using the MRI of nearly 3400 individuals including around 1000 twins. We reported both the associations between sulcal polymorphisms as well with a wide range of demographics (e.g. age, sex, handedness). Finally, we also estimated the heritability, and the genetic correlation between sulcal connections. We reported the frequency of the sulcal connections in the general population, which were hemisphere dependent. We found a sexual dimorphism of the connections, especially marked in the right hemisphere, with a CS-OTS connection more frequent in females (approximately 35–40% versus 20–25% in males) and an RS-CS connection more common in males (approximately 40–45% versus 25–30% in females). We confirmed associations between sulcal connections and characteristics of incomplete hippocampal inversion (IHI). We estimated the broad sense heritability to be 0.28–0.45 for RS-CS and CS-OTS connections, with hints of dominant contribution for the RS-CS connection. The connections appeared to share some of their genetic causing factors as indicated by strong genetic correlations. Heritability appeared much smaller for the (rarer) RS-OTS connection.
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Metadata
Title
Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability
Authors
Kevin de Matos
Claire Cury
Lydia Chougar
Lachlan T. Strike
Thibault Rolland
Maximilien Riche
Lisa Hemforth
Alexandre Martin
Tobias Banaschewski
Arun L. W. Bokde
Sylvane Desrivières
Herta Flor
Antoine Grigis
Hugh Garavan
Penny Gowland
Andreas Heinz
Rüdiger Brühl
Jean-Luc Martinot
Marie-Laure Paillère Martinot
Eric Artiges
Frauke Nees
Dimitri Papadopoulos Orfanos
Herve Lemaitre
Tomáš Paus
Luise Poustka
Sarah Hohmann
Sabina Millenet
Juliane H. Fröhner
Michael N. Smolka
Nilakshi Vaidya
Henrik Walter
Robert Whelan
Gunter Schumann
Vincent Frouin
Meritxell Bach Cuadra
Olivier Colliot
Baptiste Couvy-Duchesne
IMAGEN Consortium
Publication date
26-06-2023
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 6/2023
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-023-02663-6

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