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Published in: Archives of Gynecology and Obstetrics 1/2024

29-12-2023 | Syphilis | Maternal-Fetal Medicine

Associations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study

Authors: Mengting Sun, Manjun Luo, Tingting Wang, Taowei Zhong, Qian Chen, Hanjun Liu, Jiapeng Tang, Liuxuan Li, Jiabi Qin

Published in: Archives of Gynecology and Obstetrics | Issue 1/2024

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Abstract

Background

In recent years, syphilis is still the most common sexually transmitted disease worldwide. Pregnant women infected with syphilis can transmit it to the fetus in utero through mother-to-child transmission, which can directly lead to adverse pregnancy outcomes. The aim of this study was to investigate the associations between maternal syphilis infection and low birth weight and preterm birth in offspring.

Methods

Multinomial logistic regression model was used to analyze the associations between maternal syphilis infection and low birth weight and preterm birth, and to explore its stability through subgroup analysis.

Results

A total of 34,074 subjects were included in the study. After adjusting for potential confounders, maternal syphilis infection during pregnancy was associated with a 2.60-fold (95% CI 1.83–3.69) increased risk of low birth weight and a 1.91-fold (95% CI 1.35–2.69) increased risk of preterm birth. Subgroup analysis showed that the association was stable.

Conclusion

We found that maternal syphilis infection during pregnancy was significantly associated with an increased risk of low birth weight and preterm birth. The implementation of reasonable syphilis screening and standardized treatment and follow-up of pregnant syphilis may have important practical significance in reducing the low birth weight and preterm birth rate in offspring.
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Metadata
Title
Associations between maternal syphilis infection during pregnancy and low birth weight and preterm birth: a prospective cohort study
Authors
Mengting Sun
Manjun Luo
Tingting Wang
Taowei Zhong
Qian Chen
Hanjun Liu
Jiapeng Tang
Liuxuan Li
Jiabi Qin
Publication date
29-12-2023
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 1/2024
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-023-07321-0

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