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09-05-2024 | Suicide | Review Article

The role of SKA2 on affective disorder, post-traumatic stress disorder and suicide behavior: systematic review and in silico analysis

Authors: Thelma Beatriz González-Castro, Itzel Rodríguez-Fuentes, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Yazmín Hernández-Díaz, María Lilia López-Narváez, Edith Elena Uresti-Rivera, Jorge Luis Hernández-Vicencio

Published in: Metabolic Brain Disease | Issue 5/2024

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Abstract

Genes involved in the hypothalamic-pituitary-adrenal axis may be a robust biomarker of psychiatric disorders. Genetic polymorphisms of the SKA2 gene are associated with several behavioral disorders. In this study, we embarked on a systematic search of all possible reports of genetic association with SKA2 and affective disorder, post-traumatic stress disorder, and suicide behavior; the functional consequences of nsSNPs were explored through computational tools with an in silico analysis. Eight eligible articles were included. Our study identified that SKA2 did not show association with risk of Major Depression Disorder. Epigenetic variation at SKA2 mediates vulnerability to Post-Traumatic Stress Disorder. Studies provide strong preliminary evidence that alterations at the SKA2 gene covary with types of suicide behavior, including suicidal ideation, attempts, and completions. Results from in silico analysis predicted that I22S, I22G, I78T, A15L, D18R, R25L, N42I, Y21S, K14I, K14L, and L60R were the most structurally and functionally significant nsSNPs in SKA2. Amino acid conservation analysis revealed that the amino acids were highly conserved and some dissimilarities of mutant type amino acids from wild-type amino acids such as charge, size, and hydrophobicity were observed. In the future, SKA2 gene have the potential to be evaluated as prognostic biomarkers for diagnosis and research.
Literature
go back to reference González-Castro TB, Juárez-Rojop IE, Tovilla-Zárate CA, Ovando-Ricárdez JA, Hernández-Díaz Y, López-Narváez ML, … Rodríguez-Pérez C (2023). Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review. J Psychiatr Res 164:162–170.https://doi.org/10.1016/j.jpsychires.2023.06.011 González-Castro TB, Juárez-Rojop IE, Tovilla-Zárate CA, Ovando-Ricárdez JA, Hernández-Díaz Y, López-Narváez ML, … Rodríguez-Pérez C (2023). Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review. J Psychiatr Res 164:162–170.https://​doi.​org/​10.​1016/​j.​jpsychires.​2023.​06.​011
go back to reference Hernández-Díaz Y, Genis-Mendoza AD, González-Castro TB, Tovilla-Zárate CA, Juárez-Rojop IE, López-Narváez ML, Nicolini H (2021) Association and genetic expression between genes involved in HPA axis and suicide behavior: A systematic review. Genes (Basel) 12(10). https://doi.org/10.3390/genes12101608 Hernández-Díaz Y, Genis-Mendoza AD, González-Castro TB, Tovilla-Zárate CA, Juárez-Rojop IE, López-Narváez ML, Nicolini H (2021) Association and genetic expression between genes involved in HPA axis and suicide behavior: A systematic review. Genes (Basel) 12(10). https://​doi.​org/​10.​3390/​genes12101608
go back to reference Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Kilaru V, Jovanovic T, … Smith AK (2015) Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder. Transl Psychiatry 5(8):e627. https://doi.org/10.1038/tp.2015.105 Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Kilaru V, Jovanovic T, … Smith AK (2015) Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder. Transl Psychiatry 5(8):e627. https://​doi.​org/​10.​1038/​tp.​2015.​105
go back to reference Pandey GN, Rizavi HS, Zhang H, Bhaumik R, Ren X (2016) The expression of the suicide-associated gene SKA2 is decreased in the prefrontal cortex of suicide victims but not of nonsuicidal patients. Int J Neuropsychopharmacol 19(8). https://doi.org/10.1093/ijnp/pyw015 Pandey GN, Rizavi HS, Zhang H, Bhaumik R, Ren X (2016) The expression of the suicide-associated gene SKA2 is decreased in the prefrontal cortex of suicide victims but not of nonsuicidal patients. Int J Neuropsychopharmacol 19(8). https://​doi.​org/​10.​1093/​ijnp/​pyw015
go back to reference Pettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, Børglum AD, … Polderman TJC (2019) Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychol Med 49(7):1166–1173. https://doi.org/10.1017/s0033291718002039 Pettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, Børglum AD, … Polderman TJC (2019) Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychol Med 49(7):1166–1173. https://​doi.​org/​10.​1017/​s003329171800203​9
go back to reference Sadeh N, Wolf EJ, Logue MW, Hayes JP, Stone A, Griffin LM, … Miller MW (2016) Epigenetic Variation at SKA2 predicts suicide phenotypes and internalizing psychopathology. Depress Anxiety 33(4):308–315.https://doi.org/10.1002/da.22480 Sadeh N, Wolf EJ, Logue MW, Hayes JP, Stone A, Griffin LM, … Miller MW (2016) Epigenetic Variation at SKA2 predicts suicide phenotypes and internalizing psychopathology. Depress Anxiety 33(4):308–315.https://​doi.​org/​10.​1002/​da.​22480
go back to reference Valenzuela-García LI, Ayala-García VM, Ramos-Rosales DF, Jacquez-Flores RE, Urtiz-Estrada N, Hernández EMM, Barraza-Salas M (2023) The rs7208505 polymorphism and differential expression of the SKA2 gene in the prefrontal cortex of suicide victims from the Mexican Population. Arch Suicide Res 1–12. https://doi.org/10.1080/13811118.2023.2209155 Valenzuela-García LI, Ayala-García VM, Ramos-Rosales DF, Jacquez-Flores RE, Urtiz-Estrada N, Hernández EMM, Barraza-Salas M (2023) The rs7208505 polymorphism and differential expression of the SKA2 gene in the prefrontal cortex of suicide victims from the Mexican Population. Arch Suicide Res 1–12. https://​doi.​org/​10.​1080/​13811118.​2023.​2209155
go back to reference Yin H, Galfalvy H, Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, … Mann JJ (2016) Glucocorticoid receptor-related genes: genotype and brain gene expression relationships to suicide and major depressive disorder. Depress Anxiety 33(6):531–540. https://doi.org/10.1002/da.22499 Yin H, Galfalvy H, Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, … Mann JJ (2016) Glucocorticoid receptor-related genes: genotype and brain gene expression relationships to suicide and major depressive disorder. Depress Anxiety 33(6):531–540. https://​doi.​org/​10.​1002/​da.​22499
Metadata
Title
The role of SKA2 on affective disorder, post-traumatic stress disorder and suicide behavior: systematic review and in silico analysis
Authors
Thelma Beatriz González-Castro
Itzel Rodríguez-Fuentes
Carlos Alfonso Tovilla-Zárate
Isela Esther Juárez-Rojop
Yazmín Hernández-Díaz
María Lilia López-Narváez
Edith Elena Uresti-Rivera
Jorge Luis Hernández-Vicencio
Publication date
09-05-2024
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 5/2024
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-024-01346-3

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