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Open Access 29-10-2024 | Suicidality | Research

Adult mental health outcomes of adolescent depression and co-occurring alcohol use disorder: a longitudinal cohort study

Authors: Hannes Bohman, Sara Brolin Låftman, Iman Alaie, Richard Ssegonja, Ulf Jonsson

Published in: European Child & Adolescent Psychiatry

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Abstract

Depression and alcohol use disorder (AUD) are frequently co-occurring in adolescence, which often goes undetected in routine care. While this may potentially compromise treatment effectiveness and lead to a less favourable long-term prognosis, few longitudinal studies have followed this group into adulthood. The aim of this study was to explore the risk for adult depression, anxiety disorders, suicidality, and AUD in adolescents with concurrent depression and AUD. The study was based on the Uppsala Longitudinal Adolescent Depression Study (ULADS), a Swedish prospective cohort study. Diagnostic interviews were conducted in adolescence (age 16-17) and adulthood (around age 30). Adolescents with concurrent depression and AUD (n = 38) were compared with peers having only depression (n = 189) or neither of the conditions (n = 144). Logistic regression was used to calculate adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Adolescents with concurrent depression and AUD were more likely than their non-affected peers to experience adult depressive episodes (aOR, 5.33; 95% CI, 2.22–12.83), anxiety disorders (4.05; 1.77–9.27), suicidality (5.37; 2.28–12.66), and AUD (7.68; 2.59–22.81). Notably, 34% of adolescents with both depression and AUD subsequently experienced both these conditions as adults, compared to 7% of adolescents with only depression. Adolescents suffering only from depression were less likely than those with both conditions to experience suicidality (0.44; 0.21–0.95) and AUD in adulthood (0.18; 0.07–0.44). These findings underscore the clinical imperative to identify adolescents with this comorbidity. Recognition of the poor long-term prognosis can inform targeted interventions for this vulnerable group, ultimately improving health and well-being throughout the life course.
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Literature
9.
go back to reference Kaminer Y, Bukstein OG (eds) (2008) Adolescent substance abuse: Psychiatric comorbidity and high-risk behaviors. Routledge/Taylor & Francis Group, UK Kaminer Y, Bukstein OG (eds) (2008) Adolescent substance abuse: Psychiatric comorbidity and high-risk behaviors. Routledge/Taylor & Francis Group, UK
12.
go back to reference Kaminer Y, Connor DF, Curry JF (2007) Comorbid adolescent substance use and major depressive disorders: a review. Psychiatry 4:32–43PubMedPubMedCentral Kaminer Y, Connor DF, Curry JF (2007) Comorbid adolescent substance use and major depressive disorders: a review. Psychiatry 4:32–43PubMedPubMedCentral
13.
go back to reference Kandel DB, Johnson JG, Bird HR, Weissman MM, Goodman SH, Lahey BB, Schwab-Stone ME (1999) Psychiatric comorbidity among adolescents with substance use disorders: findings from the MECA Study. J Am Acad Child Adolesc Psychiatry 38:693–699CrossRefPubMed Kandel DB, Johnson JG, Bird HR, Weissman MM, Goodman SH, Lahey BB, Schwab-Stone ME (1999) Psychiatric comorbidity among adolescents with substance use disorders: findings from the MECA Study. J Am Acad Child Adolesc Psychiatry 38:693–699CrossRefPubMed
14.
go back to reference Pirkola T, Pelkonen M, Karlsson L, Kiviruusu O, Strandholm T, Tuisku V, Marttunen M (2011) Differences in characteristics and treatment received among depressed adolescent psychiatric outpatients with and without co-occuring alcohol misuse: a 1-year follow-up study. Depression Res Treat. https://doi.org/10.1155/2011/140868CrossRef Pirkola T, Pelkonen M, Karlsson L, Kiviruusu O, Strandholm T, Tuisku V, Marttunen M (2011) Differences in characteristics and treatment received among depressed adolescent psychiatric outpatients with and without co-occuring alcohol misuse: a 1-year follow-up study. Depression Res Treat. https://​doi.​org/​10.​1155/​2011/​140868CrossRef
22.
27.
go back to reference Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(20):22–57PubMed Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(20):22–57PubMed
28.
go back to reference Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG, Organization WH (2001) AUDIT: the alcohol use disorders identification test: guidelines for use in primary health care. World Health Organization, US Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG, Organization WH (2001) AUDIT: the alcohol use disorders identification test: guidelines for use in primary health care. World Health Organization, US
29.
32.
go back to reference StataCorp, (2021) Stata Statistical Software: Release 17. StataCorp LLC, College Station, TX StataCorp, (2021) Stata Statistical Software: Release 17. StataCorp LLC, College Station, TX
38.
go back to reference Philipson A, Alaie I, Ssegonja R, Imberg H, Copeland W, Möller M, Hagberg L, Jonsson U (2020) Adolescent depression and subsequent earnings across early to middle adulthood: a 25-year longitudinal cohort study. Epidemiol Psychiatr Sci 29(29):e123CrossRefPubMed Philipson A, Alaie I, Ssegonja R, Imberg H, Copeland W, Möller M, Hagberg L, Jonsson U (2020) Adolescent depression and subsequent earnings across early to middle adulthood: a 25-year longitudinal cohort study. Epidemiol Psychiatr Sci 29(29):e123CrossRefPubMed
41.
go back to reference Moffitt TE, Caspi A, Taylor A, Kokaua J, Milne BJ, Polanczyk G, Poulton R (2010) How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol Med 40(6):899–909CrossRefPubMed Moffitt TE, Caspi A, Taylor A, Kokaua J, Milne BJ, Polanczyk G, Poulton R (2010) How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol Med 40(6):899–909CrossRefPubMed
Metadata
Title
Adult mental health outcomes of adolescent depression and co-occurring alcohol use disorder: a longitudinal cohort study
Authors
Hannes Bohman
Sara Brolin Låftman
Iman Alaie
Richard Ssegonja
Ulf Jonsson
Publication date
29-10-2024
Publisher
Springer Berlin Heidelberg
Keyword
Suicidality
Published in
European Child & Adolescent Psychiatry
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-024-02596-3