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09-05-2024 | Stroke | Research Article

Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke

Authors: Estelle Gathy, Ninon Cadiat, Eloïse Gerardin, Julien Lambert, Benoît Herman, Mie Leeuwerck, Benoît Bihin, Yves Vandermeeren

Published in: Experimental Brain Research | Issue 6/2024

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Abstract

Cerebellar strokes induce coordination disorders that can affect activities of daily living. Evidence-based neurorehabilitation programs are founded on motor learning principles. The cerebellum is a key neural structure in motor learning. It is unknown whether and how well chronic cerebellar stroke individuals (CCSIs) can learn to coordinate their upper limbs through bimanual motor skill learning. The aim was to determine whether CCSIs could achieve bimanual skill learning through a serious game with the REAplan® robot and to compare CCSIs with healthy individuals (HIs). Over three consecutive days, sixteen CCSIs and eighteen HIs were trained on an asymmetric bimanual coordination task (“CIRCUIT” game) with the REAplan® robot, allowing quantification of speed, accuracy and coordination. The primary outcomes were the bimanual speed/accuracy trade-off (BiSAT) and bimanual coordination factor (BiCo). They were also evaluated on a bimanual REACHING task on Days 1 and 3. Correlation analyses between the robotic outcomes and clinical scale scores were computed. Throughout the sessions, BiSAT and BiCo improved during the CIRCUIT task in both HIs and CCSIs. On Day 3, HIs and CCSIs showed generalization of BiSAT, BiCo and transferred to the REACHING task. There was no significant between-group difference in progression. Four CCSIs and two HIs were categorized as “poor learners” according to BiSAT and/or BiCo. Increasing age correlated with reduced BiSAT but not BiCo progression. Over three days of training, HIs and CCSIs improved, retained, generalized and transferred a coordinated bimanual skill. There was no between-group difference, suggesting plastic compensation in CCSIs. Clinical trial NCT04642599 approved the 24th of November 2020.
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Metadata
Title
Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke
Authors
Estelle Gathy
Ninon Cadiat
Eloïse Gerardin
Julien Lambert
Benoît Herman
Mie Leeuwerck
Benoît Bihin
Yves Vandermeeren
Publication date
09-05-2024
Publisher
Springer Berlin Heidelberg
Keyword
Stroke
Published in
Experimental Brain Research / Issue 6/2024
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI
https://doi.org/10.1007/s00221-024-06830-x

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