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Current Cardiology Reports

Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention

  • Open Access
  • 20-09-2024
  • Statins
  • Lipid Abnormalities and Cardiovascular Prevention (NJ Pagidipati, Section Editor)
Published in:
Authors
Rishi Rikhi
Michael D. Shapiro
Published in
Current Cardiology Reports | Issue 12/2024

Abstract

Purpose of Review

The present review aims to summarize current evidence, explore underlying mechanisms, and help guide clinicians regarding statin therapy and diabetes risk in primary prevention.

Recent Findings

The observational and genetic epidemiology, as well as evidence from randomized controlled trials and meta-analyses, illustrate a modest, dose-dependent increase in risk of diabetes from statin therapy.

Summary

Risk of new onset diabetes from statins appears to be greatest in those near the diagnostic threshold for diabetes or with diabetes risk factors prior to statin initiation. The risk of incident diabetes is vastly offset by the cardiovascular protection offered from statin therapy and should not deter guideline recommended statin initiation in primary prevention.
Title
Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention
Authors
Rishi Rikhi
Michael D. Shapiro
Publication date
20-09-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 12/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02141-3
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