A clinical report and analysis of metachronous multiple primary cancers occurred in four sites

This case report describes a rare occurrence of quadruple primary malignancies—specifically, bilateral primary breast cancer, ovarian cancer, and pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma—and explores its potential association with hereditary tumor syndromes.

We conducted a detailed clinical and histopathological analysis of the case. Repeated imaging and pathological examinations were performed to confirm the diagnosis of each primary malignancy.

The patient was diagnosed with four distinct primary tumors, and pathological evaluation confirmed each malignancy.

This case emphasizes the importance of comprehensive pathological and genetic evaluation in patients with multiple primary malignancies. It highlights the growing incidence of such tumors among long-term cancer survivors and provides valuable insights for diagnosis and management in the context of hereditary cancer syndromes.