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Open Access 08-06-2024 | Soft Tissue Sarcoma | Orthopaedic Surgery

Local recurrence rates of superficial versus deep soft tissue sarcoma

Authors: James S. Lin, Lisa Coleman, Ryan T. Voskuil, Azeem Malik, Joel L. Mayerson, Thomas J. Scharschmidt

Published in: Archives of Orthopaedic and Trauma Surgery

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Abstract

Introduction

Soft tissue sarcomas are a group of malignancies that commonly occur in the extremities. As deep lesions may exist within the confines of the muscular fascia, we postulate that local recurrence rates are higher for superficial soft tissue sarcomas managed by the standard of care.

Materials and methods

A retrospective review was performed on 90 patients who underwent surgical resection of soft tissue sarcomas of the extremity from 2007 to 2015. Patients with minimum 2-year follow-up and adequate operative, pathologic, and clinical outcomes data were included.

Results

Mean age was 54 ± 18 years with 49 (54.4%) patients being male. Lesions in 77.8% of cases were deep, and 22.2% were superficial to fascia. Following the index surgical resection, a total of 33 (36.7%) patients had positive margins. A total of 17 (18.9%) patients had a local recurrence. Overall, 3-year survival was 92.7%, and 5-year survival was 79.0%. Five-year recurrence-free survival of deep sarcomas was 91.1% versus 58.2% of superficial lesions (p = 0.006). Patients with higher tumor depth had lower odds of experiencing a local recurrence (HR 0.26 [95% CI 0.09–0.72]). Local recurence rates was also associated with positive surgical margins on initial resection (33.3% versus 12.3%) (p = 0.027).

Conclusions

In this series, superficial tumor depth was associated with local recurrence of soft tissue sarcomas of the extremity following surgical resection. Positive surgical margins was also associated with local recurrence.
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Metadata
Title
Local recurrence rates of superficial versus deep soft tissue sarcoma
Authors
James S. Lin
Lisa Coleman
Ryan T. Voskuil
Azeem Malik
Joel L. Mayerson
Thomas J. Scharschmidt
Publication date
08-06-2024
Publisher
Springer Berlin Heidelberg
Published in
Archives of Orthopaedic and Trauma Surgery
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-024-05326-1