Skip to main content
Top

08-06-2024 | BRIEF REPORT

Small blue round cell tumor with focal epithelial differentiation harboring a novel YAP1::LEUTX fusion with poor prognosis

Authors: Xu-Xi Yang, Feng Gao, Ru Ding, Jia Wei, Xiao-Mei Zhu, Qi‐Xing Gong

Published in: Virchows Archiv

Login to get access

Excerpt

 While the small blue round cell tumor encompasses a group of malignancies with varying origins of differentiation, recent molecular genetic advancements have enabled a more precise definition and revolutionized diagnosis of these tumors. Herein, we report a unique case of small blue round cell tumor exhibiting focal epithelial differentiation and harboring a novel YAP1::LEUTX fusion gene, which does not fit in any known pathological categories. After a thorough investigation of the tumor’s morphology and immunophenotype, along with a comprehensive literature review, we propose a provisional category of LEUTX-rearranged tumors, which has distinct clinicopathological features. …
Appendix
Available only for authorised users
Literature
17.
18.
go back to reference Lebrun L, Allard-Demoustiez S, Gilis N, et al (2023) Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as “CNS embryonal tumor with BRD4–LEUTX fusion”. Acta Neuropathol Commun 11:46. https://doi.org/10.1186/s40478-023-01549-2 Lebrun L, Allard-Demoustiez S, Gilis N, et al (2023) Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as “CNS embryonal tumor with BRD4–LEUTX fusion”. Acta Neuropathol Commun 11:46. https://​doi.​org/​10.​1186/​s40478-023-01549-2
Metadata
Title
Small blue round cell tumor with focal epithelial differentiation harboring a novel YAP1::LEUTX fusion with poor prognosis
Authors
Xu-Xi Yang
Feng Gao
Ru Ding
Jia Wei
Xiao-Mei Zhu
Qi‐Xing Gong
Publication date
08-06-2024
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-024-03839-z