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17-06-2024 | Sleeve Gastrectomy | Original Contributions

Impact of Sleeve Gastrectomy on Uric Acid Levels in Patients with Obesity: A Comparative Study

Authors: Zahra Davoudi, Amir Shokuhi Sabet, Hossein Toreyhi, Fariborz Rashnoo, Mahbobeh Taheri, Faraneh Farsad

Published in: Obesity Surgery | Issue 7/2024

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Abstract

Purpose

This study aimed to investigate the incidence of hyperuricemia in obese individuals with or without metabolic syndrome and assess the impact of sleeve gastrectomy surgery on the amelioration of hyperuricemia and metabolic syndrome.

Materials and Methods

A prospective study was conducted on patients with obesity who were candidates for laparoscopic sleeve gastrectomy. These patients were diligently followed for 1 year after the surgical procedure. The assessment of hyperuricemia and metabolic syndrome was carried out both before and one year after the surgery.

Results

A total of 198 patients (30 males and 168 females) underwent sleeve gastrectomy. After 1 year, there was a notable decline in the prevalence of hyperuricemia, decreasing from 77 to 36 cases (a reduction of 46.75%) among females and from 18 to 8 cases (a reduction of 44.44%) among males. Prior to the surgery, 60.6% of patients (120 out of 198) were diagnosed with metabolic syndrome, and 36.7% of these patients exhibited improvements in their metabolic syndrome status. Among individuals with metabolic syndrome, significant enhancements were observed in various anthropometric and laboratory measurements, including reductions in hypertriglyceridemia, hyperuricemia, and hypercholesteremia. A logistic regression analysis revealed that in females, changes in creatinine, glomerular filtration rate (GFR), weight loss, body mass index (BMI), and triglyceride reduction all had a notable impact on the likelihood of recovering from hyperuricemia.

Conclusion

These findings underscore the clinical relevance of this surgical intervention in managing obesity-related conditions.

Graphical Abstract

Appendix
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Metadata
Title
Impact of Sleeve Gastrectomy on Uric Acid Levels in Patients with Obesity: A Comparative Study
Authors
Zahra Davoudi
Amir Shokuhi Sabet
Hossein Toreyhi
Fariborz Rashnoo
Mahbobeh Taheri
Faraneh Farsad
Publication date
17-06-2024
Publisher
Springer US
Published in
Obesity Surgery / Issue 7/2024
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-024-07356-5

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