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Current Pulmonology Reports

Open Access 30-08-2024 | Sleep-Related Breathing Disorders | Review

Effect of Continuous Positive Airway Pressure Treatment on Cardiovascular Outcomes in Obstructive Sleep Apnea

Authors: Baran Balcan, Yuksel Peker

Published in: Current Pulmonology Reports

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Abstract

Purpose of Review

Obstructive Sleep Apnea (OSA) is a common sleep disorder with significant cardiovascular implications, affecting a broad adult demographic. This review explores OSA’s link to cardiovascular diseases and assesses Continuous Positive Airway Pressure (CPAP) therapy’s role in managing these conditions.

Recent Findings

OSA is associated with coronary heart disease, heart failure, hypertension, arrhythmias, and pulmonary hypertension, due to intermittent hypoxia, inflammation, and sympathetic activation. CPAP therapy, known for enhancing sleep and reducing daytime fatigue, has varying impacts on cardiovascular health.

Summary

While results on coronary heart disease are mixed, CPAP shows promise in improving heart failure outcomes, reducing hypertension, and managing arrhythmias, with potential benefits for pulmonary hypertension through improved hemodynamics. This underscores CPAP’s value in OSA’s holistic management, highlighting its beyond-respiratory benefits. However, adherence challenges persist, calling for more research on CPAP’s long-term cardiovascular effects. This advocates a multidisciplinary approach to OSA, considering its extensive health consequences.
Literature
1.
2.
Somers VK, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular nursing. J Am Coll Cardiol. 2008;52(8):686–717.CrossRefPubMed
3.
4.
5.
Marin JM, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046–53.CrossRefPubMed
6.
McEvoy RD, et al. CPAP for Prevention of Cardiovascular Events in obstructive sleep apnea. N Engl J Med. 2016;375(10):919–31.CrossRefPubMed
7.
Peker Y, et al. Effect of positive Airway pressure on Cardiovascular outcomes in Coronary Artery Disease patients with Nonsleepy Obstructive Sleep Apnea. The RICCADSA Randomized Controlled Trial. Am J Respir Crit Care Med. 2016;194(5):613–20.CrossRefPubMed
8.
Sánchez-de-la-Torre M, et al. Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial. Lancet Respir Med. 2020;8(4):359–67.CrossRefPubMed
9.
Sánchez-de-la-Torre M, et al. Adherence to CPAP Treatment and the risk of Recurrent Cardiovascular events: a Meta-analysis. JAMA. 2023;330(13):1255–65.CrossRefPubMedPubMedCentral
10.
Bradley TD, Floras JS. Obstructive sleep apnoea and its cardiovascular consequences. Lancet. 2009;373(9657):82–93.CrossRefPubMed
11.
Mansfield DR, et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med. 2004;169(3):361–6.CrossRefPubMed
12.
13.
Peppard PE, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84.CrossRefPubMed
14.
Montesi SB, et al. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012;8(5):587–96.CrossRefPubMedPubMedCentral
15.
Barbé F, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA. 2012;307(20):2161–8.CrossRefPubMed
16.
Gami AS, et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol. 2007;49(5):565–71.CrossRefPubMed
17.
Kanagala R, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation. 2003;107(20):2589–94.CrossRefPubMed
18.
Simantirakis EN, et al. Severe bradyarrhythmias in patients with sleep apnoea: the effect of continuous positive airway pressure treatment: a long-term evaluation using an insertable loop recorder. Eur Heart J. 2004;25(12):1070–6.CrossRefPubMed
19.
Chaouat A, et al. Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med. 1995;151(1):82–6.CrossRefPubMed
20.
Sajkov D, et al. Continuous positive airway pressure treatment improves pulmonary hemodynamics in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;165(2):152–8.CrossRefPubMed
21.
Arias MA, et al. Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure: a randomized, controlled cross-over study. Eur Heart J. 2006;27(9):1106–13.CrossRefPubMed
Metadata
Title
Effect of Continuous Positive Airway Pressure Treatment on Cardiovascular Outcomes in Obstructive Sleep Apnea
Authors
Baran Balcan
Yuksel Peker
Publication date
30-08-2024

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