Skip to main content
Top

17-06-2024 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Globus sensation in obstructive sleep apnea patients; A cross-sectional study of 120 patients

Authors: Reza Erfanian, Rozhina Pouremamali, Raha Zamani, Seyedeh Atiyeh Moazeni, Pedram Borghei

Published in: Sleep and Breathing

Login to get access

Abstract

Purpose

Globus pharyngeus (GP) is a common complaint in many disciplines, especially otolaryngology. Pharyngeal symptoms and abnormalities, including GP, are frequent in obstructive sleep apnea (OSA) patients. This study aims to investigate globus sensation in non-operated OSA patients.

Methods

After translation and validation, the Laryngopharyngeal Measure of Perceived Sensation (LUMP) was administered to 120 untreated OSA patients. All patients underwent polysomnography and thorough physical examination. The association between LUMP scores and OSA measures was evaluated.

Results

LUMP score had a significant correlation with the Epworth Sleepiness Scale (ESS) (Spearman’s ρ = 0.269, p = 0.004), and BMI (Spearman’s ρ = 0.249, p = 0.007), the anatomical position of the tongue (ρ = -0.191, p = 0.04) and the Friedman grade of tonsils (ρ = 0.241, p = 0.01). It correlated with SpO2 nadir, though it did not reach statistical significance.

Conclusion

The results of our study depict a relationship between a self-report measure of globus sensation and daytime sleepiness, BMI and tonsil size. In the absence of a direct relationship between OSA severity parameters and GP, we hypothesize a role for shared comorbidities and anatomical phenotypes. The increased frequency of GP in OSA patients should be considered when evaluating the complications of surgical interventions in these patients.
Literature
1.
go back to reference Kirch S et al (2013) Globus pharyngeus: effectiveness of treatment with proton pump inhibitors and gabapentin. Ann Otol Rhinol Laryngol 122(8):492–495CrossRefPubMed Kirch S et al (2013) Globus pharyngeus: effectiveness of treatment with proton pump inhibitors and gabapentin. Ann Otol Rhinol Laryngol 122(8):492–495CrossRefPubMed
2.
go back to reference Fukui A et al (2018) Relation between globus pharyngeus and OSA in patients examined simultaneously by PSG and pH monitor: A cross sectional study. Auris Nasus Larynx 45(5):1033–1040CrossRefPubMed Fukui A et al (2018) Relation between globus pharyngeus and OSA in patients examined simultaneously by PSG and pH monitor: A cross sectional study. Auris Nasus Larynx 45(5):1033–1040CrossRefPubMed
3.
go back to reference Malcomson KG (1968) Globus hystericus vel pharyngis (a recommaissance of proximal vagal modalities). J Laryngol Otol 82(3):219–230CrossRefPubMed Malcomson KG (1968) Globus hystericus vel pharyngis (a recommaissance of proximal vagal modalities). J Laryngol Otol 82(3):219–230CrossRefPubMed
6.
go back to reference Järvenpää P, Arkkila P, Aaltonen LM (2018) Globus pharyngeus: a review of etiology, diagnostics, and treatment. Eur Arch Otorhinolaryngol 275(8):1945–1953CrossRefPubMed Järvenpää P, Arkkila P, Aaltonen LM (2018) Globus pharyngeus: a review of etiology, diagnostics, and treatment. Eur Arch Otorhinolaryngol 275(8):1945–1953CrossRefPubMed
7.
go back to reference Melancon CC et al (2020) The development and validation of the laryngopharyngeal measure of perceived sensation. Laryngoscope 130(12):2767–2772CrossRefPubMed Melancon CC et al (2020) The development and validation of the laryngopharyngeal measure of perceived sensation. Laryngoscope 130(12):2767–2772CrossRefPubMed
8.
go back to reference Semelka M, Wilson J, Floyd R (2016) Diagnosis and Treatment of Obstructive Sleep Apnea in Adults. Am Fam Physician 94(5):355–360PubMed Semelka M, Wilson J, Floyd R (2016) Diagnosis and Treatment of Obstructive Sleep Apnea in Adults. Am Fam Physician 94(5):355–360PubMed
9.
go back to reference Senaratna CV et al (2017) Prevalence of obstructive sleep apnea in the general population: A systematic review. Sleep Med Rev 34:70–81CrossRefPubMed Senaratna CV et al (2017) Prevalence of obstructive sleep apnea in the general population: A systematic review. Sleep Med Rev 34:70–81CrossRefPubMed
11.
go back to reference Culebras A, Anwar S (2018) Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia. Curr Neurol Neurosci Rep 18(8):53CrossRefPubMed Culebras A, Anwar S (2018) Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia. Curr Neurol Neurosci Rep 18(8):53CrossRefPubMed
12.
go back to reference Young T et al (2008) Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 31(8):1071–1078PubMedPubMedCentral Young T et al (2008) Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 31(8):1071–1078PubMedPubMedCentral
13.
go back to reference Marin JM et al (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365(9464):1046–1053CrossRefPubMed Marin JM et al (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365(9464):1046–1053CrossRefPubMed
14.
go back to reference Kato MG et al (2018) The Incidence and Characterization of Globus Sensation, Dysphagia, and Odynophagia Following Surgery for Obstructive Sleep Apnea. J Clin Sleep Med 14(1):127–132CrossRefPubMedPubMedCentral Kato MG et al (2018) The Incidence and Characterization of Globus Sensation, Dysphagia, and Odynophagia Following Surgery for Obstructive Sleep Apnea. J Clin Sleep Med 14(1):127–132CrossRefPubMedPubMedCentral
15.
go back to reference Johns MW (1993) Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale. Chest 103(1):30–36CrossRefPubMed Johns MW (1993) Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale. Chest 103(1):30–36CrossRefPubMed
16.
go back to reference Sigurdardottir FD et al (2022) Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project. J Sleep Res 31(5):e13581CrossRefPubMed Sigurdardottir FD et al (2022) Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project. J Sleep Res 31(5):e13581CrossRefPubMed
17.
go back to reference Friedman M, Salapatas AM, Bonzelaar LB (2017) Updated Friedman Staging System for Obstructive Sleep Apnea. Adv Otorhinolaryngol 80:41–48PubMed Friedman M, Salapatas AM, Bonzelaar LB (2017) Updated Friedman Staging System for Obstructive Sleep Apnea. Adv Otorhinolaryngol 80:41–48PubMed
18.
go back to reference Torre C et al (2018) Hypopharyngeal evaluation in obstructive sleep apnea with awake flexible laryngoscopy: Validation and updates to Cormack-Lehane and Modified Cormack-Lehane scoring systems. Clin Otolaryngol 43(3):823–827CrossRefPubMed Torre C et al (2018) Hypopharyngeal evaluation in obstructive sleep apnea with awake flexible laryngoscopy: Validation and updates to Cormack-Lehane and Modified Cormack-Lehane scoring systems. Clin Otolaryngol 43(3):823–827CrossRefPubMed
19.
20.
go back to reference Beaton DE et al (2000) Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 25(24):3186–91CrossRefPubMed Beaton DE et al (2000) Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 25(24):3186–91CrossRefPubMed
21.
go back to reference Agada FO, Coatesworth AP, Grace AR (2007) Retroverted epiglottis presenting as a variant of globus pharyngeus. J Laryngol Otol 121(4):390–392CrossRefPubMed Agada FO, Coatesworth AP, Grace AR (2007) Retroverted epiglottis presenting as a variant of globus pharyngeus. J Laryngol Otol 121(4):390–392CrossRefPubMed
22.
go back to reference Ju G et al (2013) Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. J Psychosom Res 75(6):551–555CrossRefPubMed Ju G et al (2013) Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. J Psychosom Res 75(6):551–555CrossRefPubMed
23.
go back to reference Lundkvist K, Friberg D (2010) Pharyngeal disturbances in OSAS patients before and 1 year after UPPP. Acta Otolaryngol 130(12):1399–1405CrossRefPubMed Lundkvist K, Friberg D (2010) Pharyngeal disturbances in OSAS patients before and 1 year after UPPP. Acta Otolaryngol 130(12):1399–1405CrossRefPubMed
24.
go back to reference Bhutada AM, Broughton WA, Focht Garand KL (2020) Obstructive sleep apnea syndrome (OSAS) and swallowing function-a systematic review. Sleep Breath 24(3):791–799CrossRefPubMed Bhutada AM, Broughton WA, Focht Garand KL (2020) Obstructive sleep apnea syndrome (OSAS) and swallowing function-a systematic review. Sleep Breath 24(3):791–799CrossRefPubMed
25.
go back to reference Kato T et al (2016) Subjective oropharyngeal symptoms for abnormal swallowing in Japanese patients with obstructive sleep apnea syndrome: a descriptive questionnaire study. Cranio 34(2):95–99CrossRefPubMed Kato T et al (2016) Subjective oropharyngeal symptoms for abnormal swallowing in Japanese patients with obstructive sleep apnea syndrome: a descriptive questionnaire study. Cranio 34(2):95–99CrossRefPubMed
27.
go back to reference Valbuza JS et al (2011) Oropharyngeal examination as a predictor of obstructive sleep apnea: pilot study of gag reflex and palatal reflex. Arq Neuropsiquiatr 69(5):805–808CrossRefPubMed Valbuza JS et al (2011) Oropharyngeal examination as a predictor of obstructive sleep apnea: pilot study of gag reflex and palatal reflex. Arq Neuropsiquiatr 69(5):805–808CrossRefPubMed
28.
go back to reference Zhang D et al (2021) Excessive Daytime Sleepiness in Depression and Obstructive Sleep Apnea: More Than Just an Overlapping Symptom. Front Psychiatry 12:710435CrossRefPubMedPubMedCentral Zhang D et al (2021) Excessive Daytime Sleepiness in Depression and Obstructive Sleep Apnea: More Than Just an Overlapping Symptom. Front Psychiatry 12:710435CrossRefPubMedPubMedCentral
29.
go back to reference Siau R, Kinshuck A, Houghton L (2021) The assessment and management of globus pharyngeus. Br J Hosp Med 82(3):1–8CrossRef Siau R, Kinshuck A, Houghton L (2021) The assessment and management of globus pharyngeus. Br J Hosp Med 82(3):1–8CrossRef
Metadata
Title
Globus sensation in obstructive sleep apnea patients; A cross-sectional study of 120 patients
Authors
Reza Erfanian
Rozhina Pouremamali
Raha Zamani
Seyedeh Atiyeh Moazeni
Pedram Borghei
Publication date
17-06-2024
Publisher
Springer International Publishing
Published in
Sleep and Breathing
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-024-03087-0
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Webinar | 06-02-2024 | 20:00 (CET)

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by: Viatris

Developed by: Springer Healthcare
Live Webinar | 01-10-2024 | 12:30 (CEST)

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

Live: Tuesday 1st October 2024, 12:30-14:00 (CEST)

In this live webinar, Professor Martin Dreyling and an esteemed, international panel of CAR-T experts will discuss the very latest data on the safety, efficacy and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL, as presented at ASH 2023, EU CAR-T 2024, and EHA 2024. 

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by: Novartis Pharma AG

Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare