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Open Access 06-01-2022 | Simvastatin | Original Article

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

Authors: Xiaoyun Wu, Ziwei Hu, Junjie Zhou, Jin Liu, Ping Ren, Xi Huang

Published in: Journal of Cardiovascular Translational Research | Issue 4/2022

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Abstract 

The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE-/- mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS.
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Metadata
Title
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
Authors
Xiaoyun Wu
Ziwei Hu
Junjie Zhou
Jin Liu
Ping Ren
Xi Huang
Publication date
06-01-2022
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 4/2022
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-021-10196-8

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