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Published in: Inflammopharmacology 2/2024

12-02-2024 | Septicemia | Review

Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review

Authors: Yutong Song, Jing Hao, Yanhua Liu

Published in: Inflammopharmacology | Issue 2/2024

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Abstract

Objective

It was to systematically evaluate the effect of corticosteroids on 28d all-cause mortality (ACM), in-hospital death rate, and ICU death rate in critically ill sepsis patients.

Methods

PubMed, Embase, and Medline databases were used to screen the published literatures on the therapeutic effect of corticosteroids in the treatment of critically ill sepsis patients. After evaluating the quality of the included literatures, RevMan 5.3 software was used for meta-analysis. 4524 literatures regarding the application of corticosteroids to treat critically ill sepsis patients were preliminarily searched. After screening was carried out, 9 literatures were finally included. 2,850 patients were treated with corticosteroids and 2867 patients were treated with placebo.

Results

The meta-analysis of the effect of corticosteroids versus placebo on 28dACM showed [OR = 0.87, 95% CI 0.78–0.98, Z = 2.22, P = 0.03], P < 0.05; the meta-analysis of the outcome of corticosteroids versus placebo on ICU death rate showed [OR = 0.77, 95% CI 0.63–0.94, Z = 2.60, P = 0.009], P < 0.05; and the meta-analysis of the effect of corticosteroids versus placebo on in-hospital death rate showed [OR = 0.80, 95% CI 0.66–0.96, Z = 2.34, P = 0.002], P < 0.05.

Conclusion

In summary, corticosteroids can reduce the death rate of critically ill sepsis patients to a certain extent and have good clinical application value.
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Metadata
Title
Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review
Authors
Yutong Song
Jing Hao
Yanhua Liu
Publication date
12-02-2024
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 2/2024
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01426-3

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