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Open Access 16-05-2024 | Sectio Caesarea | Maternal-Fetal Medicine

Effect of administration routes of oxytocin on hemoglobin in neonates with delayed umbilical cord clamping: a multi-centre randomized controlled clinical trial

Authors: Lu Mei, Ning Gu, Yan Zhou, Zhiqun Wang, Ling Yang, Li Chen, Chunxia Li, Yimin Dai

Published in: Archives of Gynecology and Obstetrics | Issue 2/2024

Abstract

Purpose

To evaluate the effect of intravenous infusion versus intramyometrial injection of oxytocin on hemoglobin levels in neonates with delayed umbilical cord clamping during cesarean section.

Methods

The multi-centre randomized controlled trial was performed at three hospitals from February to June 2023. Women with term singleton gestations scheduled for cesarean delivery were allocated to receive an intravenous infusion of 10 units of oxytocin or a myometrial injection of 10 units of oxytocin during the surgery. The primary outcome was neonatal hemoglobin at 48 to 96 h after birth. Secondary outcomes were side-effects of oxytocin, postpartum haemorrhage, phototherapy for jaundice, feeding at 1 month, maternal and neonatal morbidity and re-admissions.

Results

A total of 360 women were randomized (180 women in each group). The mean neonatal hemoglobin did not show a significant difference between the intravenous infusion group (194.3 ± 21.7 g/L) and the intramyometrial groups (195.2 ± 24.3 g/L) (p = 0.715). Secondary neonatal outcomes, involving phototherapy for jaundice, feeding at 1 month and neonatal intensive care unit admission were similar between the two groups. The maternal outcomes did not differ significantly between the two groups, except for a 200 mL higher intraoperative infusion volume observed in the intravenous group compared to the intramyometrial group.

Conclusion

Among women undergoing elective cesarean delivery of term singleton pregnancies, there was no significant difference in neonatal hemoglobin at 48 to 96 h after birth between infants with delayed cord clamping, whether the oxytocin was administrated by intravenous infusion or intramyometrial injection.

Trial registration

Chinese Clinical trial registry: ChiCTR2300067953 (1 February 2023).

Available only for authorised users

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Title: Effect of administration routes of oxytocin on hemoglobin in neonates with delayed umbilical cord clamping: a multi-centre randomized controlled clinical trial
Authors: Lu Mei
Ning Gu
Yan Zhou
Zhiqun Wang
Ling Yang
Li Chen
Chunxia Li
Yimin Dai
Publication date: 16-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Sectio Caesarea
Sectio Ceasarea
Phototherapy
Published in: Archives of Gynecology and Obstetrics / Issue 2/2024
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-024-07543-w

ERS Congress 2024

Springer Medicine

Effect of administration routes of oxytocin on hemoglobin in neonates with delayed umbilical cord clamping: a multi-centre randomized controlled clinical trial

Abstract

Purpose

Methods

Results

Conclusion

Trial registration

ERS Congress 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Trial registration

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