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22-09-2023 | Schizophrenia | Psychiatry and Preclinical Psychiatric Studies - Review Article

Pharmacological modulation of HIF-1 in the treatment of neuropsychiatric disorders

Authors: Diksha Sharma, Heena Khan, Amit Kumar, Amarjot Kaur Grewal, Kamal Dua, Thakur Gurjeet Singh

Published in: Journal of Neural Transmission | Issue 12/2023

Abstract

Hypoxia-inducible factor 1 has been identified as an important therapeutic target in psychiatric illnesses. Hypoxia is a condition in which tissues do not receive enough oxygen, resulting in less oxidative energy production. HIF-1, the master regulator of molecular response to hypoxia, is destabilized when oxygen levels fall. HIF-1, when activated, increases the gene transcription factors that promote adaptive response and longevity in hypoxia. HIF-regulated genes encode proteins involved in cell survival, energy metabolism, angiogenesis, erythropoiesis, and vasomotor control. Multiple genetic and environmental variables contribute to the pathophysiology of psychiatric disease. This review focuses on the most recent findings indicating the role of oxygen deprivation in CNS damage, with strong attention on HIF-mediated pathways. Several pieces of evidence suggested that, in the case of hypoxia, induction and maintenance of HIF-1 target genes may help reduce nerve damage. Major new insights into the molecular mechanisms that control HIF's sensitivity to oxygen are used to make drugs that can change the way HIF works as a therapeutic target for some CNS diseases.

Amodeo G, Trusso MA, Fagiolini A (2017) Depression and inflammation: disentangling a clear yet complex and multifaceted link. Neuropsychiatry 7(4):448–457

Arora B, Khan H, Grewal AK, Singh TG (2023) Mechanistic insights on the role of nitric oxide in ischemia-reperfusion injury. InNitric oxide in health and disease. Academic Press, pp 275–285. https://doi.org/10.1016/B978-0-443-13342-8.00004-1 CrossRef

Bauer ME, Teixeira AL (2019) Inflammation in psychiatric disorders: what comes first? Ann N Y Acad Sci 1437(1):57–67. https://doi.org/10.1111/nyas.13712 CrossRefPubMed

Behl T, Kaur D, Sehgal A, Singh S, Sharma N, Zengin G, Andronie-Cioara FL et al (2021a) Role of monoamine oxidase activity in Alzheimer’s disease: an insight into the therapeutic potential of inhibitors. Molecules 26(12):3724. https://doi.org/10.3390/molecules26123724 CrossRefPubMedPubMedCentral

Behl T, Kaur G, Sehgal A, Bhardwaj S, Singh S, Buhas C, Judea-Pusta C et al (2021b) Multifaceted role of matrix metalloproteinases in neurodegenerative diseases: pathophysiological and therapeutic perspectives. Int J Mol Sci 22(3):1413. https://doi.org/10.3390/ijms22031413 CrossRefPubMedPubMedCentral

Bray NJ, O’Donovan MC (2018) The genetics of neuropsychiatric disorders. Brain Neurosci Adv. https://doi.org/10.1177/2398212818799271 CrossRefPubMedPubMedCentral

Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V (2010) Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum Genomics 5(1):1–26. https://doi.org/10.1186/1479-7364-5-1-30 CrossRef

Brockmann MD, Kukovic M, Schönfeld M, Sedlacik J, Hanganu-Opatz IL (2013) Hypoxia-ischemia disrupts directed interactions within neonatal prefrontal-hippocampal networks. PLoS ONE 8(12):e83074. https://doi.org/10.1371/journal.pone.0083074 CrossRefPubMedPubMedCentral

Deng Q, Chang Y, Cheng X, Luo X, Zhang J, Tang X (2018) Postconditioning with repeated mild hypoxia protects neonatal hypoxia-ischemic rats against brain damage and promotes rehabilitation of brain function. Brain Res Bull 139:31–37. https://doi.org/10.1016/j.brainresbull.2018.02.006 CrossRefPubMed

Depression WHO (2017) Other common mental disorders: global health estimates. World Health Organization, Geneva, p 24

Duelli R, Enerson BE, Gerhart DZ, Drewes LR (2000) Expression of large amino acid transporter LAT1 in rat brain endothelium. J Cereb Blood Flow Metab 20(11):1557–1562. https://doi.org/10.1097/00004647-200011000-00005 CrossRefPubMed

Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12):1116–1127. https://doi.org/10.1016/j.biopsych.2006.02.013 CrossRefPubMed

Edition F (2013) Diagnostic and statistical manual of mental disorders. Am Psychiatric Assoc 21(21):591–643

Eftekharian MM, Ghafouri-Fard S, Noroozi R, Omrani MD, Arsang-Jang S, Ganji M et al (2018) Cytokine profile in autistic patients. Cytokine 108:120–126. https://doi.org/10.1016/j.cyto.2018.03.034 CrossRefPubMed

Ehrenreich H, Degner D, Meller J, Brines M, Behe M, Hasselblatt M et al (2004) Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry 9(1):42–54. https://doi.org/10.1038/sj.mp.4001442 CrossRefPubMed

Eissa N, Sadeq A, Sasse A, Sadek B (2020) Role of neuroinflammation in autism spectrum disorder and the emergence of brain histaminergic system. Lessons also for BPSD. Front Pharmacol 11:886. https://doi.org/10.3389/fphar.2020.00886 CrossRefPubMedPubMedCentral

Fan T, Hu Y, Xin J, Zhao M, Wang J (2020) Analyzing the genes and pathways related to major depressive disorder via a systems biology approach. Brain Behav 10(2):e01502. https://doi.org/10.1002/brb3.1502 CrossRefPubMed

Flügel D, Görlach A, Michiels C, Kietzmann T (2007) Glycogen synthase kinase-3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol Cell Biol 27:3253–3265. https://doi.org/10.1128/MCB.00015-07 CrossRefPubMedPubMedCentral

Gu YZ, Hogenesch JB, Bradfield CA (2000) The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40(1):519–561 CrossRefPubMed

Guo S, Miyake M, Liu KJ, Shi H (2009) Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment. J Neurochem 108(5):1309–1321. https://doi.org/10.1111/j.1471-4159.2009.05877.x CrossRefPubMedPubMedCentral

Gupta A, Khan H, Kaur A, Singh TG (2021) Novel targets explored in the treatment of alcohol withdrawal syndrome. CNS Neurol Disord Drug Targets 20(2):158–173. https://doi.org/10.2174/1871527319999201118155721 CrossRefPubMed

Henderson M, Harvey SB, Øverland S, Mykletun A, Hotopf M (2011) Work and common psychiatric disorders. J R Soc Med 104(5):198–207. https://doi.org/10.1258/jrsm.2011.100231 CrossRefPubMedPubMedCentral

Hollander JA, Cory-Slechta DA, Jacka FN, Szabo ST, Guilarte TR, Bilbo SD et al (2020) Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. Neuropsychopharmacol 45(7):1086–1096. https://doi.org/10.1038/s41386-020-0648-5 CrossRef

Hollocks MJ, Lerh JW, Magiati I, Meiser-Stedman R, Brugha TS (2018) Anxiety and depression in adults with autism spectrum disorder: a systematic review and meta-analysis. Psychol Med. https://doi.org/10.1017/s0033291718002283 CrossRefPubMed

Howlin P (2000) Outcome in adult life for more able individuals with autism or Asperger syndrome. Autism 4(1):63–83. https://doi.org/10.1177/1362361300004001005 CrossRef

Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC (2003) Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 23(24):9361–9374. https://doi.org/10.1128/MCB.23.24.9361-9374.2003 CrossRefPubMedPubMedCentral

Isung J, Aeinehband S, Mobarrez F, Mårtensson B, Nordström P, Åsberg M, Piehl F et al (2012) Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. Transl Psychiatry 2(11):e196–e196. https://doi.org/10.1038/tp.2012.123 CrossRefPubMedPubMedCentral

Kaelin WG, Ratcliffe PJ (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30(4):393–402. https://doi.org/10.1016/j.molcel.2008.04.009 CrossRefPubMed

Kalra P, Khan H, Kaur A, Singh TG (2022) Mechanistic insight on autophagy modulated molecular pathways in cerebral ischemic injury: from preclinical to clinical perspective. Neurochem Res. https://doi.org/10.1007/s11064-021-03500-0 CrossRefPubMed

Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000) Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci 97(19):10430–10435. https://doi.org/10.1073/pnas.190332597 CrossRefPubMedPubMedCentral

Kang I, Kondo D, Kim J, Lyoo IK, Yurgelun-Todd D, Hwang J et al (2021) Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression. Med Hypotheses 146:110398. https://doi.org/10.1016/j.mehy.2020.110398 CrossRefPubMed

Kast RE (2008) How lithium treatment generates neutrophilia by enhancing phosphorylation of GSK-3, increasing HIF-1 levels and how this path is important during engraftment. Bone Marrow Transplant 41:23–26. https://doi.org/10.1038/sj.bmt.1705872 CrossRefPubMed

Kaur A, Singh TG, Khan H, Kumar M, Singh N, Abdel-Daim MM (2022) Neuroprotective effect of piclamilast-induced post-ischemia pharmacological treatment in mice. Neurochem Res. https://doi.org/10.1007/s11064-022-03609-w CrossRefPubMed

Ke Q, Costa M (2006) Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70(5):1469–1480. https://doi.org/10.1124/mol.106.027029 CrossRefPubMed

Kewley RJ, Whitelaw ML, Chapman-Smith A (2004) The mammalian basic helix–loop–helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol 36(2):189–204. https://doi.org/10.1016/S1357-2725(03)00211-5 CrossRefPubMed

Khan H, Gupta A, Singh TG, Kaur A (2021a) Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury. Pharmacol Rep 73:1240–1254. https://doi.org/10.1007/s43440-021-00258-8 CrossRefPubMed

Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG (2021b) Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res J 1761:147399. https://doi.org/10.1016/j.brainres.2021.147399 CrossRef

Khan H, Bangar A, Grewal AK, Bansal P, Singh TG (2022a) Caspase-mediated regulation of the distinct signaling pathways and mechanisms in neuronal survival. Int Immunopharmacol 110:108951. https://doi.org/10.1016/j.intimp.2022.108951 CrossRefPubMed

Khan H, Garg N, Singh TG, Kaur A, Thapa K (2022b) Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases. Neurochem Res 47(5):1125–1149. https://doi.org/10.1007/s11064-021-03521-9 CrossRefPubMed

Khan H, Grewal AK, Singh TG (2022c) Mitochondrial dynamics related neurovascular approaches in cerebral ischemic injury. Mitochondrion 66:54–66. https://doi.org/10.1016/j.mito.2022.08.001 CrossRefPubMed

Khan H, Grewal AK, Singh TG (2022d) Pharmacological postconditioning by protocatechuic acid attenuates brain injury in ischemia-reperfusion (I/R) mice model: implications of nuclear factor erythroid-2-related factor pathway. Neuroscience 491:23–31. https://doi.org/10.1016/j.neuroscience.2022.03.016 CrossRefPubMed

Khan H, Singh TG, Dahiya RS, Abdel-Daim MM (2022e) α-Lipoic acid, an organosulfur biomolecule a novel therapeutic agent for neurodegenerative disorders: an mechanistic perspective. Neurochem Res 47(7):1853–1864. https://doi.org/10.1007/s11064-022-03598-w CrossRefPubMed

Leconte C, Léger M, Boulouard M, Tixier E, Fréret T, Bernaudin M et al (2012) Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression. Behav Brain Res 230(1):78–84. https://doi.org/10.1016/j.bbr.2012.01.054 CrossRefPubMed

Li Y, Zhong W, Jiang Z, Tang X (2019) New progress in the approaches for blood–brain barrier protection in acute ischemic stroke. Brain Res Bull 144:46–57. https://doi.org/10.1016/j.brainresbull.2018.11.006 CrossRefPubMed

Li G, Zhao M, Cheng X, Zhao T, Feng Z, Zhao Y et al (2020) FG-4592 improves depressive-like behaviors through HIF-1-mediated neurogenesis and synapse plasticity in rats. Neurotherapeutics 17(2):664–675. https://doi.org/10.1007/s13311-019-00807-3 CrossRefPubMed

Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X et al (2022) Antidepressant-like effect and mechanism of ginsenoside Rd on rodent models of depression. Drug Des Devel Ther 16:843. https://doi.org/10.2147/DDDT.S351421 CrossRefPubMedPubMedCentral

Lis K (2008) Insulin-like growth factor 1 (IGF-1) and growth hormone (hGH) as the markers of osteoarthritis. Pol Orthop Traumatol 73(1):49–52

Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, Cui R (2017) The role of neural plasticity in depression: from hippocampus to prefrontal cortex. J Neural Transplant Plast. https://doi.org/10.1155/2017/6871089 CrossRef

LLorens-Martin M, Torres-Aleman I, Trejo JL (2009) Reviews: mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. Neurosci 15(2):134–148. https://doi.org/10.1177/1073858408331371 CrossRef

Lugo-Marin J, Magan-Maganto M, Rivero-Santana A, Cuellar-Pompa L, Alviani M, Jenaro-Rio C, Diez E et al (2019) Prevalence of psychiatric disorders in adults with autism spectrum disorder: A SYSTEMATIC review and meta-analysisRes. Autism Spectr Disord 59:22–33. https://doi.org/10.1016/j.rasd.2018.12.004 CrossRef

McCutcheon RA, Marques TR, Howes OD (2020) Schizophrenia—an overview. JAMA Psychiat 77(2):201–210. https://doi.org/10.1001/jamapsychiatry.2019.3360 CrossRef

Miguel PM, Schuch CP, Rojas JJ, Carletti JV, Deckmann I, Martinato LH et al (2015) Neonatal hypoxia-ischemia induces attention-deficit hyperactivity disorder-like behavior in rats. Behav Neurosci 129(3):309. https://doi.org/10.1037/bne0000063 CrossRefPubMed

Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K, Iqbal KH (1993) Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer’ s disease. Arch Biochem Biophys 301(1):41–52. https://doi.org/10.1006/abbi.1993.1112 CrossRefPubMed

Mitroshina EV, Savyuk MO, Ponimaskin E, Vedunova MV (2021) Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2021.703084 CrossRefPubMedPubMedCentral

Modabbernia A, Velthorst E, Reichenberg A (2017) Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism 8(1):1–16. https://doi.org/10.1186/s13229-017-0121-4 CrossRef

Mudgil M, Gupta N, Nagpal M, Pawar P (2012) Nanotechnology: a new approach for ocular drug delivery system. Int J Pharm Pharm Sci 4(2):105–112

Nagu P, Parashar A, Behl T, Mehta V (2021) CNS implications of COVID-19: a comprehensive review. Rev Neurosci 32(2):219–234. https://doi.org/10.1515/revneuro-2020-0070 CrossRefPubMed

Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL et al (2015) HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLoS ONE 10(3):e0119762. https://doi.org/10.1371/journal.pone.0119762 CrossRefPubMedPubMedCentral

Ng F, Berk M, Dean O, Bush AI (2008) Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11(6):851–876. https://doi.org/10.1017/s1461145707008401 CrossRefPubMed

Nzou G, Wicks RT, VanOstrand NR, Mekky GA, Seale SA, El-Taibany A et al (2020) Multicellular 3D neurovascular unit model for assessing hypoxia and neuroinflammation induced blood-brain barrier dysfunction. Sci Rep 10(1):1–15. https://doi.org/10.1038/s41598-020-66487-8 CrossRef

Okazaki S, Boku S, Watanabe Y, Otsuka I, Horai T, Morikawa R et al (2022) Polymorphisms in the hypoxia inducible factor binding site of the macrophage migration inhibitory factor gene promoter in schizophrenia. PLoS ONE 17(3):e0265738. https://doi.org/10.1371/journal.pone.0265738 CrossRefPubMedPubMedCentral

Oman J, Ubah D, Rivas D, Triyasakorn K, Bhushan A, Lai J, Awale P (2021) Valproic acid alters the expression of HIF-1α in embryonic brains in a valproic acid rodent model of autism. FASEB J. https://doi.org/10.1096/fasebj.2021.35.S1.03260 CrossRef

Onishi Y, Hiraiwa M, Kamada H, Iezaki T, Yamada T, Kaneda K, Hinoi E (2019) Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells. FEBS Open Bio 9(2):241–247 CrossRefPubMedPubMedCentral

Prabhakar NK, Khan H, Grewal AK, Singh TG (2022) Intervention of neuroinflammation in the traumatic brain injury trajectory: in vivo and clinical approaches. Int Immunopharmacol 108:108902. https://doi.org/10.1016/j.intimp.2022.108902 CrossRefPubMed

Rani R, Kumar A, Jaggi AS, Singh N (2021) Pharmacological investigations on efficacy of Phlorizin asodium-glucose co-transporter (SGLT) inhibitor in mouse model ofintracerebroventricular streptozotocin induced dementia of AD type. J Basic Clin Physiol Pharmacol 32(6):1057–1064. https://doi.org/10.1515/jbcpp-2020-0330 CrossRefPubMed

Rihal V, Kaur A, Singh TG, Abdel-Daim MM (2022) Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders. Psychiat Res 14:114782. https://doi.org/10.1016/j.psychres.2022.114782 CrossRef

Roman FS, Truchet B, Marchetti E, Chaillan FA, Soumireu-Mourat B (1999) Correlations between electrophysiological observations of synaptic plasticity modifications and behavioral performance in mammals. Prog Neurobiol 58(1):61–87. https://doi.org/10.1016/S0301-0082(98)00076-8 CrossRefPubMed

Rosenstein JM, Krum JM, Ruhrberg C (2008) VEGF in the nervous system. VEGF Dev. https://doi.org/10.1007/978-0-387-78632-2_8 CrossRef

Russo VC, Gluckman PD, Feldman EL, Werther G (2005) The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev 26(7):916–943. https://doi.org/10.1210/er.2004-0024 CrossRefPubMed

Sayal K, Prasad V, Daley D, Ford T, Coghill D (2018) ADHD in children and young people: prevalence, care pathways, and service provision. Lancet Psychiatry 5(2):75–186. https://doi.org/10.1016/s2215-0366(17)30167-0 CrossRef

Semenza GL (1998) Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 8(5):588–594. https://doi.org/10.1016/s0959-437x(98)80016-6 CrossRefPubMed

Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE. https://doi.org/10.1126/stke.4072007cm8 CrossRefPubMed

Sharma B, Sharma A (2012) Future prospect of nanotechnology in development of anti-ageing formulations. Int J Pharm Pharm Sci 4(3):57–66

Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208(7):1367–1376. https://doi.org/10.1084/jem.20110278 CrossRefPubMedPubMedCentral

Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F et al (2013) The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. Prog Neuropsychopharmacol Biol Psychiatry 43:222–229. https://doi.org/10.1016/j.pnpbp.2013.01.003 CrossRefPubMed

Shrivastav S, Sindhu R, Kumar S, Kumar P (2009) Anti-psoriatic and phytochemical evaluation of Thespesia populnea bark extracts. Int J Pharm Pharm Sci 1(1):76–85

Şimşek F, Işık Ü, Aktepe E, Kılıç F, Şirin FB, Bozkurt M (2021) Comparison of serum VEGF, IGF-1, and HIF-1α levels in children with autism spectrum disorder and healthy controls. CcJ Autism Dev Disord 51(10):3564–3574. https://doi.org/10.1007/s10803-020-04820-w CrossRef

Singh V, Arora S, Kaur R, Shri R (2021) Memory improvement effects of Ganoderma mediosinense in mice via its anticholinergic and antioxidant activities. Alzheimer’s Dement 17:e050707. https://doi.org/10.1002/alz.050707 CrossRef

Siniscalco D, Schultz S, Brigida AL, Antonucci N (2018) Inflammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals 11(2):56. https://doi.org/10.3390/ph11020056 CrossRefPubMedPubMedCentral

Skogstrand K, Hagen CM, Borbye-Lorenzen N, Christiansen M, Bybjerg-Grauholm J, Bækvad-Hansen M (2019) Reduced neonatal brain-derived neurotrophic factor is associated with autism spectrum disorders. Transl Psychiatry 9(1):1–9. https://doi.org/10.1038/s41398-019-0587-2 CrossRef

Strowitzki MJ, Cummins EP, Taylor CT (2019) Protein hydroxylation by hypoxia-inducible factor (HIF) hydroxylases: unique or ubiquitous? Cells 8(5):384. https://doi.org/10.3390/cells8050384 CrossRefPubMedPubMedCentral

Tărlungeanu DC, Deliu E, Dotter CP, Kara M, Janiesch PC, Scalise M (2016) Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder. Cell 167(6):1481–1494 CrossRefPubMedPubMedCentral

Thakur AK, Chellappan DK, Dua K, Mehta M, Satija S, Singh I (2020) Patented therapeutic drug delivery strategies for targeting pulmonary diseases. Expert Opin Ther Pat 30(5):375–387. https://doi.org/10.1080/13543776.2020.1741547 CrossRefPubMed

Tiwari P, Khan H, Singh TG, Grewal AK (2022) Poly (ADP-ribose) polymerase: an overview of mechanistic approaches and therapeutic opportunities in the management of stroke. Neurochem Res 47:1830–1852. https://doi.org/10.1007/s11064-022-03595-z CrossRefPubMed

Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 57(1):67–81 CrossRefPubMed

Vengellur A, Phillips JM, Hogenesch JB, LaPres JJ (2005) Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. Physiol Genomics 22(3):308–318. https://doi.org/10.1152/physiolgenomics.00045.2004 CrossRefPubMed

Vogelzangs N, Beekman A, De Jonge P, Penninx BJTp (2013) Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry 3(4):e249–e249. https://doi.org/10.1038/tp.2013.27 CrossRefPubMedPubMedCentral

Wang XX, Zha YY, Yang B, Chen L, Wang M (2016) Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro. Int J Nanomed. https://doi.org/10.2147/IJN.S104856 CrossRef

Wright M, Di Ciano P, Brands B (2020) Use of cannabidiol for the treatment of anxiety: a short synthesis of pre-clinical and clinical evidence. Cannabis Cannabinoid Res 5(3):191–196. https://doi.org/10.1089/can.2019.0052 CrossRefPubMedPubMedCentral

Xia Y, Choi HK, Lee K (2012) Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. Eur J Med Chem 49:24–40. https://doi.org/10.1016/j.ejmech.2012.01.033 CrossRefPubMed

Xiao Q, Qin X (2017) Expression of hypoxia-inducible factor-1 α in children with attention deficit hyperactivity disorder and its relationship with respiratory function. Chin J Prim Med Pharm 12:1390–1393

Xu LH, Xie H, Shi ZH, Du LD, Wing YK, Li AM, Ke Y et al (2015) Critical role of endoplasmic reticulum stress in chronic intermittent hypoxia-induced deficits in synaptic plasticity and long-term memory. Antioxid Redox Signal 23(9):695–710. https://doi.org/10.1089/ars.2014.6122 CrossRefPubMedPubMedCentral

Ye Z, Kappelmann N, Moser S, Smith GD, Burgess S, Jones PB, Khandaker GM (2021) Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank. EClinicalMedicine 38:100992 CrossRefPubMedPubMedCentral

Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR (2008) Induction of HIF-1α expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol 217(3):674–685. https://doi.org/10.1002/jcp.21537 CrossRefPubMedPubMedCentral

Zhang Z, Yan J, Chang Y, ShiDu Yan S, Shi H (2011) Hypoxia inducible factor-1 as a target for neurodegenerative diseases. Curr Med Chem 18(28):4335–4343. https://doi.org/10.2174/092986711797200426 CrossRefPubMedPubMedCentral

Zimna A, Kurpisz M (2015) Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies. Biomed Res Int. https://doi.org/10.1155/2015/549412 CrossRefPubMedPubMedCentral

Title: Pharmacological modulation of HIF-1 in the treatment of neuropsychiatric disorders
Authors: Diksha Sharma
Heena Khan
Amit Kumar
Amarjot Kaur Grewal
Kamal Dua
Thakur Gurjeet Singh
Publication date: 22-09-2023
Publisher: Springer Vienna
Keywords: Schizophrenia
Anxiety
Autism Spectrum Disorder
Published in: Journal of Neural Transmission / Issue 12/2023
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-023-02698-3

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Pharmacological modulation of HIF-1 in the treatment of neuropsychiatric disorders

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