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17-08-2023 | SARS-CoV-2 | Case Report

Immune-mediated cerebellitis following SARS-CoV-2 infection—a case report and review of the literature

Authors: Florence Plumacker, Nicolas Lambert, Pierre Maquet

Published in: Journal of NeuroVirology | Issue 4/2023

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Abstract

The coronavirus disease 2019 (COVID-19) can be associated with a wide variety of neurological manifestations. Some of these manifestations might result from the ongoing systemic inflammatory state, but the pathophysiology of specific neurologic involvement is still unclear. In this article, we report a patient who developed an isolated cerebellar syndrome 9 weeks after an episode of COVID-19. The reverse-transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 was positive on cerebrospinal fluid (CSF). A post-infectious–autoimmune-cerebellitis following COVID-19 was suspected, and the patient was treated with corticosteroids, leading to a complete recovery within a few weeks. We review the other cases of COVID-19-associated cerebellar syndrome reported so far and discuss the potential pathophysiological mechanisms underlying this neurologic manifestation.
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Metadata
Title
Immune-mediated cerebellitis following SARS-CoV-2 infection—a case report and review of the literature
Authors
Florence Plumacker
Nicolas Lambert
Pierre Maquet
Publication date
17-08-2023
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 4/2023
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-023-01163-x

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