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21-10-2021 | Sarcopenia | Nephrology - Original Paper

Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis

Authors: Petrini Plytzanopoulou, Panagiotis Politis, Theodora Papachrysanthou, Christos Andriopoulos, Athina Drakou, Evangelos Papachristou, Miltiadis Papastamatiou, Marios Papasotiriou

Published in: International Urology and Nephrology | Issue 7/2022

Abstract

Purpose

Sarcopenia is a clinical condition that comprises declined skeletal muscle (SM) mass and SM strength, and is a risk factor for physical disability, impaired quality of life, and advanced morbidity and mortality in patients on hemodialysis (HD). The existing difficulty in evaluating SM mass and consequently of sarcopenia, with affordable and practical methods in clinical practice, is well established. The purpose of this study is to examine the creatinine index (CrI), a surrogate of SM mass, as a potential predictive marker of sarcopenia.

Methods

In this cross-sectional study, we included 130 patients on HD with a mean age of 66.17 ± 12.47 years. SM mass and SM strength were evaluated with CrI and hand grip strength, respectively. Anthropometric, adiposity, nutritional, and biochemical assessments were also performed. Partial correlation and multivariate regression analyses were applied to investigate the association between CrI and SM strength.

Results

Correlation analysis showed that mid-arm circumference, calf circumference, Geriatric nutritional index, and albumin-to-total protein ratio were positively associated with SM strength. Multivariate model indicated that CrI (β = 2.05, p < 0.001) and dialysis duration (β =− 0.53, p = 0.001) were independently related to SM strength. The significant positive correlation between CrI and SM strength remained unaffected even after adjusting for potential confounders.

Conclusions

Creatinine Index was significantly associated with SM strength highlighting its value as a new emerging practical in clinical setting sarcopenia predictive marker in HD patients.

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Title: Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis
Authors: Petrini Plytzanopoulou
Panagiotis Politis
Theodora Papachrysanthou
Christos Andriopoulos
Athina Drakou
Evangelos Papachristou
Miltiadis Papastamatiou
Marios Papasotiriou
Publication date: 21-10-2021
Publisher: Springer Netherlands
Keyword: Sarcopenia
Published in: International Urology and Nephrology / Issue 7/2022
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-021-03032-0

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Abstract

Purpose

Methods

Results

Conclusions

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