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20-11-2023 | Sarcopenia | Original Article

Association of the psoas muscle index with the survival of patients on a waiting list for lung transplantation: a Japanese single-institution study

Authors: Yuuki Matsui, Takashi Kanou, Eriko Fukui, Toru Kimura, Naoko Ose, Soichiro Funaki, Yasushi Shintani

Published in: Surgery Today

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Abstract

Purposes

Some predictive markers of death have been reported for patients on the waiting list for lung transplantation (LTx). We assessed whether or not the preoperative psoas muscle index (PMI) correlates with waitlist mortality.

Methods

In 81 patients with end-stage lung disease on the waiting list for LTx between 2011 and 2020 at Osaka University Hospital, we examined the association between baseline characteristics, including the diagnosis, respiratory function test results, blood collection items, steroid use, and psoas muscle mass on computed tomography, and survival during the waiting period using Kaplan–Meier curves and Cox proportional hazard regression models.

Results

Thirty-three patients (41%) died during follow-up. Univariate and multivariate analyses showed that patients with a low PMI had a higher rate of death during follow-up than those with a high PMI (p < 0.0001 and 0.0002, respectively). In addition, a diagnosis of interstitial pneumonia (hazard ratio 3.30, 95% confidence interval 1.52–7.17, p = 0.0025) and low albumin level (hazard ratio 2.21, 95% confidence interval 1.02–4.80, p = 0.0449) were also significant predictors of survival.

Conclusion

A low PMI at registration is associated with a decreased survival time among LTx candidates and it may be a predictive factor of mortality in patients waiting for LTx.
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Metadata
Title
Association of the psoas muscle index with the survival of patients on a waiting list for lung transplantation: a Japanese single-institution study
Authors
Yuuki Matsui
Takashi Kanou
Eriko Fukui
Toru Kimura
Naoko Ose
Soichiro Funaki
Yasushi Shintani
Publication date
20-11-2023
Publisher
Springer Nature Singapore
Keyword
Sarcopenia
Published in
Surgery Today
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-023-02765-y