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Current Cardiology Reports

Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis

  • 22-05-2024
  • Sarcoidosis
  • Nuclear Cardiology (V Dilsizian, Section Editor)
Published in:
Authors
Ashwin Singh Parihar
Ines Valenta
Salwa Mikhail
Alessio Imperiale
Thomas H. Schindler
Published in
Current Cardiology Reports | Issue 7/2024

Abstract

Purpose of the Review

Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization.

Recent Findings

Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function.

Summary

This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.
Title
Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis
Authors
Ashwin Singh Parihar
Ines Valenta
Salwa Mikhail
Alessio Imperiale
Thomas H. Schindler
Publication date
22-05-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 7/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02070-1
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME