Skip to main content

Advanced Search

Projected result for your current search:: 0

Search Operators:

You can use operators in your search query to narrow down your results even more. Click on the search operator to see an explanation of how it works.
Finds documents with exactly this word group, in exactly this word order and spelling (e.g. "employer branding").
Finds documents with both search terms (e.g. sales AND bonus).
Finds documents with one or the other search term (e.g. porsche OR volkswagen).
Finds documents with all search terms. Blank space is understood as AND (e.g. man robot production).
Finds documents with no appearance of the word behind NOT (e.g. ford NOT "harrison ford").
Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g. COUNT(gear)>8).
Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g. NEAR(recruit, professionals, 20)).
Finds documents with the search term in word versions or composites. The asterisk * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g. lightweight*, *lightweight, *lightweight*).
Finds documents with the search term in different spellings. "?" allows only one character (e.g. organi?ation).
Special characters are understood as AND (e.g. Miller Bros. & Sons).
 Log in
Top
Japanese Journal of Radiology

FDG uptake in upper abdominal lymph node as a distinctive pattern in sarcoidosis

Authors
Ryogo Minamimoto
Yumi Abe
Ryota Morimoto
Rintato Ito
Naotoshi Fujita
Toyoaki Murohara
Katsuhiko Kato
Shinji Naganawa
Published in
Japanese Journal of Radiology

Abstract

Objectives

To evaluate the distribution patterns of sarcoidosis involvement on FDG-PET/CT in patients with known or suspected cardiac sarcoidosis (CS), with a particular focus on upper abdominal lymph nodes (LN) (periportal LN [PLN], anterior pancreaticoduodenal LN [APDLN], and posterior pancreaticoduodenal LN [PPDLN]) and the association of them with other lesions and myocardium.

Methods

We identified 861 FDG-PET/CT scans performed between July 2016 and August 2024 in patients with known or suspected CS, and included 178 cases for analysis of FDG uptake patterns suggestive of sarcoid involvement. FDG-positive LNs or regions were classified as sarcoidosis-related based on treatment response, characteristic uptake patterns, or histological confirmation. The occurrence ratio of FDG-positive lymph nodes or regions was also assessed in relation to myocardial FDG uptake patterns.

Results

FDG uptake was observed most frequently in hilar and mediastinal LNs (79% and 76%, respectively). Upper abdominal LN uptake was observed in 49.4% of patients, most commonly in the PLN (31.5%), APDLN (38.2%), and PPDLN (37.1%). Heatmap analyses revealed strong co-occurrence between thoracic and upper abdominal LNs, suggesting a lymphatic dissemination pattern. Peripheral LNs such as axillary, subclavian, and inguinal/pelvic stations demonstrated low uptake and minimal co-occurrence.

Conclusions

FDG-PET/CT provides valuable insight into the structured lymphatic dissemination of sarcoidosis. Frequent FDG uptake in upper abdominal lymph nodes, particularly when accompanied by thoracic involvement, represents a characteristic finding in sarcoidosis. Recognition of this pattern can improve diagnostic accuracy and help differentiate sarcoidosis from other systemic diseases.

Secondary abstract

This study assessed lymph node involvement on FDG-PET/CT in patients with suspected or known cardiac sarcoidosis, revealing distinct dissemination patterns into the upper abdomen. These findings enhance understanding of disease pathophysiology and may improve diagnostic evaluation.
Title
FDG uptake in upper abdominal lymph node as a distinctive pattern in sarcoidosis
Authors
Ryogo Minamimoto
Yumi Abe
Ryota Morimoto
Rintato Ito
Naotoshi Fujita
Toyoaki Murohara
Katsuhiko Kato
Shinji Naganawa
Publication date
05-02-2026
Publisher
Springer Nature Singapore
Published in
Japanese Journal of Radiology
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-025-01935-x
This content is only visible if you are logged in and have the appropriate permissions.

How can your team use biomarkers to improve management of AD? (Link opens in a new window)

1.75 AMA PRA Category 1 Credits™

Explore using biomarker testing to interpret results and guide treatment strategies through an interactive patient simulation and unique educational escape rooms.

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Lilly
Learn more TODO (Link opens in a new window)

How can you integrate PET into your practice? (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)™

PET imaging is playing an increasingly critical role in managing AD. Our expert-led program will empower you with practical strategies and real-world case studies to effectively integrate it into clinical practice.

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Lilly
Learn more TODO (Link opens in a new window)
Image Credits
Alzheimer’s disease in the biomarker era: preparing the multidisciplinary care team/© Springer Healthcare IME, Navigating neuroimaging in Alzheimer’s care: Practical applications and strategies for integration/© Springer Health+ IME