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Rheumatology Sarcoidosis

Sarcoidosis

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

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Editor's Choice

Ulcerative cutaneous sarcoidosis: a diagnostic challenge

Diagnosing cutaneous sarcoidosis can be challenging due to its diverse skin manifestations, which can mimic other conditions. In this case, the patient presented with chronic leg ulcers.

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Cardio-rheumatology: an emerging specialty

Cardio-rheumatology focuses on addressing the intricate relationship between systemic inflammation and CV diseases. Discover the most common manifestations as well as the recommended diagnostic workup and imaging options. 

Corticosteroids for hydrocephalus in neurosarcoidosis

Hydrocephalus is a rare complication of neurosarcoidosis, usually requiring prompt high-dose IV corticosteroids and neurosurgical treatment. Neurosurgery can have severe complications, but select cases may be eligible for drug treatment only.

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Case Studies

Ulcerative cutaneous sarcoidosis: a diagnostic challenge

Diagnosing cutaneous sarcoidosis can be challenging due to its diverse skin manifestations, which can mimic other conditions. In this case, the patient presented with chronic leg ulcers.

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Current Reviews

Redefining Cardiac Sarcoidosis with Advanced Imaging and Therapeutic Strategies

Cardiac sarcoidosis (CS) is an elusive, yet potentially life-threatening disease marked by granulomatous inflammation of the myocardium, which can lead to arrhythmias, heart failure, and sudden cardiac death. Although corticosteroids have long …

Multimodality Imaging in the Contemporary Work-Up of Cardiac Sarcoidosis

Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas, which can involve various organs, including the heart. Cardiac sarcoidosis (CS) is a potentially life-threatening manifestation of systemic …

Atrial FDG Uptake: Etiologies, Clinical Significance, and Implications

Fluorodeoxyglucose (FDG) positron emission tomography (PET) is widely used for both oncological and cardiac applications. In cardiology, FDG-PET has become invaluable for assessing infection, such as prosthetic valve endocarditis [ 1 ], as well as …

Echocardiography and Heart Failure: An Echocardiographic Decision Aid for the Diagnosis and Management of Cardiomyopathies

The lifetime risk of heart failure in the United States is approximately 24% and by 2030 it is projected that 8.5 million Americans will have heart failure [ 1 – 3 ]. Echocardiography has a preeminent role in the diagnosis, prognostication …

Further Reading

Symptomatic Sarcoidosis Treated with Acthar® Gel: Insights from a Physician-Reported Chart Review

Sarcoidosis is a rare, idiopathic, chronic granulomatous disease of unknown cause that primarily affects the lungs in 80–90% of cases [ 1 , 2 ]. The prevalence of sarcoidosis in the United States (U.S.) is estimated to be 60 per 100,000 adults, and …

FDG uptake in upper abdominal lymph node as a distinctive pattern in sarcoidosis

Sarcoidosis is a multisystem granulomatous disease that has nonspecific clinical manifestations that commonly affect the pulmonary system in at least 90% of sarcoidosis patients. In 10–30% of cases there is involvement of other organs such as the …

Novel clinical application of urinary angiotensin-converting enzyme assay in renal sarcoidosis: a retrospective observational study

Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas, mainly affecting the lungs, eyes, and skin [ 1 – 4 ]. The prevalence of renal involvement ranges from approximately −1% to 5% [ 2 , 4 – 6 ]. Common renal …

Role of concomitant endomyocardial biopsy in non-ischemic cardiomyopathy with ventricular arrhythmias

In patients with cardiomyopathy and ventricular arrhythmias (VAs), such as premature ventricular contractions or ventricular tachycardia (VT), identifying the etiology of cardiomyopathy plays a key role in determining treatment strategies …

Image Credits
Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com