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Rheumatology Sarcoidosis

Sarcoidosis

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

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Editor's Choice

Cardio-rheumatology: an emerging specialty

Cardio-rheumatology focuses on addressing the intricate relationship between systemic inflammation and CV diseases. Discover the most common manifestations as well as the recommended diagnostic workup and imaging options. 

Corticosteroids for hydrocephalus in neurosarcoidosis

Hydrocephalus is a rare complication of neurosarcoidosis, usually requiring prompt high-dose IV corticosteroids and neurosurgical treatment. Neurosurgery can have severe complications, but select cases may be eligible for drug treatment only.

Complications from conduction system pacing

Conduction system pacing (CSP) is a novel technique that involves pacing the His-Purkinje system instead of the traditional right ventricular apex, and which aims to avoid the adverse effects of the latter. CSP is gaining popularity but its long-term efficacy and challenges remain uncertain. 

Concurrent sarcoidosis and hypersensitivity pneumonitis

Two patients presented with concomitant features of sarcoidosis and hypersensitivity pneumonitis, suggesting a common biologic background, at least in some cases.

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Case Studies

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Corticosteroids for hydrocephalus in neurosarcoidosis

Hydrocephalus is a rare complication of neurosarcoidosis, usually requiring prompt high-dose IV corticosteroids and neurosurgical treatment. Neurosurgery can have severe complications, but select cases may be eligible for drug treatment only.

Complications from conduction system pacing

Conduction system pacing (CSP) is a novel technique that involves pacing the His-Purkinje system instead of the traditional right ventricular apex, and which aims to avoid the adverse effects of the latter. CSP is gaining popularity but its long-term efficacy and challenges remain uncertain. 

Current Reviews

Fluocinolone acetonide 0.2 µg/day intravitreal implant in non-infectious uveitis affecting the posterior segment: EU expert user panel consensus-based clinical recommendations

Non-infectious uveitis affecting the posterior segment of the eye (NIU-PS) is an inflammatory disease, which may result in severe visual impairment and tissue damage when it is not adequately treated and controlled [ 1 ]. Additionally, the …

The burden of cough in idiopathic pulmonary fibrosis and other interstitial lung diseases: a systematic evidence synthesis

  • Open Access
  • Cough
  • Review

Interstitial lung disease (ILD) encompasses a heterogenous group of respiratory conditions characterised by inflammation and/or fibrosis of the lung parenchyma [ 1 , 2 ]. Idiopathic pulmonary fibrosis (IPF), the most common and well-studied type of …

Causes of Oral Granulomatous Disorders: An Update and Narrative Review of the Literature

Granulomatous diseases include a diverse range of chronic inflammatory disorders with a wide variety of pathologies and clinical characteristics. In particular, the orofacial region can be affected by granulomatous conditions—whether as an …

Diagnostic delay of sarcoidosis: an integrated systematic review

Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown cause, which can affect any organ, but primarily affects the lungs. Sarcoidosis can present as acute or chronic disease - acute sarcoidosis, with joint pain, erythema …

Further Reading

Granulomatous nephropathy: have you thought about genetics?

We report here the case of a 16-year-old girl with chronic kidney disease, where biopsy revealed tubulointerstitial nephropathy with granulomas. Initial treatments included immunosuppressive therapy unless genetic testing with exome sequencing …

Increased retinal thickness in sarcoidosis patients with ocular system involvement visualized with optical coherence tomography: a cross-sectional study

This study investigates the thickness of retinal structures in patients with neurosarcoidosis (NS) and ocular sarcoidosis (OS). We compared the central macular thickness (CMT), retinal thickness (RT), central nerve fiber layer (RNFL) thickness …

Obinutuzumab in Rituximab-resistant and recurrent membranous nephropathy: a case-series

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults [ 1 ]. Untreated, up to 50% of patients with membranous nephropathy may develop end-stage kidney disease (ESKD) within ten years [ 1 , 2 ]. The recognition of membranous …

Cerebral vasculitis related to neurosarcoidosis: a case series and systematic literature review

Cerebral vasculitis is a rare but severe manifestation of neurosarcoidosis (NS) that has received little attention. The aim of the present study was to characterize clinical and diagnostic features as well as potential treatment strategies of …