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Journal of Medical Case Reports
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Open Access 19-03-2025 | Salivary Gland Cancer | Case report

Salivary gland adenoid cystic carcinoma presenting as a large metastatic hepatic mass: a case report

Authors: Matthew Walker, Alisa Dewald, Abdelrhman Refaey, Ivan Berezowski, Jacob Newman, Mamoun Younes, Stephen Gray

Published in: Journal of Medical Case Reports | Issue 1/2025

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Abstract

Background

Salivary gland tumors are rare, representing 6–8% of head and neck tumors. Adenoid cystic carcinoma represents approximately 10% of salivary gland tumors. The preferential sites of metastases are the lung and bone, followed by the brain and liver. Liver metastasis as the initial clinical manifestation of parotid gland adenoid cystic carcinoma is very rare.

Case presentation

We report the case of a 29-year-old African American male patient with a metastatic salivary gland tumor who presented initially with a large hepatic mass. He complained of right upper quadrant pain and early satiety. Abdominal computed tomography revealed hepatomegaly with a large mass centered in the left lobe measuring 14 cm. A computed tomography scan revealed innumerable bilateral pulmonary nodules measuring up to 8 mm, favoring metastases. Initial histopathological examination of the liver biopsy specimens revealed a well-differentiated carcinoma characterized by a distinctive myxoid stroma, consistent with metastatic adenoid cystic carcinoma. The patient underwent transcatheter arterial chemoembolization and was discharged with a hematology–oncology follow-up. A presumptive diagnosis of stage IV adenoid cystic carcinoma with lung and liver metastases was made. The patient was given cisplatin and vinorelbine.

Conclusion

Metastatic parotid gland adenoid cystic carcinoma with initial clinical manifestation as a liver mass is very rare and was pathologically confirmed in this patient by its histological appearance. This case emphasizes the need for clinicians to consider salivary gland tumors in the differential diagnosis of unexplained hepatic lesions.
Literature
1.
El-Naggar AK, Chan JKC, Grandis JR, et al. World Health Organization classification of tumours of head and neck. Lyon: IAARC; 2017.
2.
3.
Li JY, Liu P, Lei YL, Mao ZQ, Hu F, Liu JB. Liver metastasis from adenoid cystic carcinoma of the submandibular gland: a case report. Int J Clin Exp Pathol. 2020;13(3):550–5.PubMedPubMedCentral
4.
5.
6.
7.
8.
9.
10.
11.
12.
Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016;7:66239–54.CrossRefPubMedPubMedCentral
13.
14.
Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest. 2019;129(10):4276–89. https://​doi.​org/​10.​1172/​JCI128227.CrossRefPubMedPubMedCentral
15.
16.
Garg N, Tomar R, Goyal S, Singh UR. Isolated liver metastases in an adenoid cystic carcinoma of the submandibular gland on fine needle aspiration cytology: an unusual presentation. Cytopathology. 2014;25:137–8 (Crossref. PubMed).CrossRefPubMed
17.
Deshpande AH, Kelkar AA. Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: cytologic diagnosis. Diagn Cytopathol. 2009;37:45–7 (Crossref. PubMed).CrossRefPubMed
18.
Spolverato G, Fite J, Bishop J, Argani P, Pawlik TM. Liver metastasis as the initial presentation of adenoid cystic carcinoma. Dig Dis Sci. 2014;59:2004–6 (Crossref. PubMed).CrossRefPubMedPubMedCentral
19.
Metadata
Title
Salivary gland adenoid cystic carcinoma presenting as a large metastatic hepatic mass: a case report
Authors
Matthew Walker
Alisa Dewald
Abdelrhman Refaey
Ivan Berezowski
Jacob Newman
Mamoun Younes
Stephen Gray
Publication date
19-03-2025
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2025
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-025-05151-z

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