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Inflammation Research
Published in: Inflammation Research 7/2023

28-06-2023 | Review

Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions

Authors: Shubham Kumar Rai, Divya Singh, Pranita P. Sarangi

Published in: Inflammation Research | Issue 7/2023

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Abstract

Background

RhoG is a multifaceted member of the Rho family of small GTPases, sharing the highest sequence identity with the Rac subfamily members. It acts as a molecular switch, when activated, plays a central role in regulating the fundamental processes in immune cells, such as actin-cytoskeleton dynamics, transendothelial migration, survival, and proliferation, including immunological functions (e.g., phagocytosis and trogocytosis) during inflammatory responses.

Method

We have performed a literature review based on published original and review articles encompassing the significant effect of RhoG on immune cell functions from central databases, including PubMed and Google Scholar.

Results and conclusions

Recently published data shows that the dynamic expression of different transcription factors, non-coding RNAs, and the spatiotemporal coordination of different GEFs with their downstream effector molecules regulates the cascade of Rho signaling in immune cells. Additionally, alterations in RhoG-specific signaling can lead to physiological, pathological, and developmental adversities. Several mutations and RhoG-modulating factors are also known to pre-dispose the downstream signaling with abnormal gene expression linked to multiple diseases. This review focuses on the cellular functions of RhoG, interconnecting different signaling pathways, and speculates the importance of this small GTPase as a prospective target against several pathological conditions.
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Metadata
Title
Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions
Authors
Shubham Kumar Rai
Divya Singh
Pranita P. Sarangi
Publication date
28-06-2023
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 7/2023
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-023-01761-9

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